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'''the second meeting''' | '''the second meeting''' | ||
We read two papers. | |||
1.Folding DNA to create nanoscale shapes and patterns | |||
*Paul W. K. Rothemund | |||
Summary: | |||
A simple method for folding long, single-stranded DNA into arbitrary two-dimensional shapes was invented. | |||
The design for a desired shape is made by rater-filling the shape with scaffold and choosing staple strands to hold the scaffold in place. Once synthesized and mixed, the staple and scaffold strands self-assemble, and desired shapes such as squares and stars can be made. | |||
=== May === | === May === | ||
Revision as of 06:01, 13 June 2013
April
the first meeting
Team Todai nanORFEVRE was fixed as the name of our team. Yearly schedule was checked.
We read in turn following two reviews of the structural DNA nanotechnology.
- Andre V. Pinheiro1, Dongran Han1,2, William M. Shih3,4,5* and Hao Yan1,2* Challenges and opportunities for structural DNA nanotechnology
- Nadrian C. Seeman Nanomaterials Based on DNA Department of Chemistry, New York University, New York, New York 10003
the second meeting
We read two papers.
1.Folding DNA to create nanoscale shapes and patterns
- Paul W. K. Rothemund
Summary: A simple method for folding long, single-stranded DNA into arbitrary two-dimensional shapes was invented. The design for a desired shape is made by rater-filling the shape with scaffold and choosing staple strands to hold the scaffold in place. Once synthesized and mixed, the staple and scaffold strands self-assemble, and desired shapes such as squares and stars can be made.
May
the third meeting
We read in turn following two papers.
- Qiao Jiang,†Chen Song,†Jeanette Nangreave,‡Xiaowei Liu,‡Lin Lin,§Dengli Qiu,#Zhen-Gang Wang,†Guozhang Zou,†Xingjie Liang,†Hao Yan,*,‡and Baoquan Ding DNA Origami as a Carrier for Circumvention of Drug Resistance
The summary is as follows: DNA origami as carrierThe DNA origami nanostructure, which is biocompatible and have spatially addressable surfaces for multi-functional activity, is presented as a promising drug carrier system in the treatment of cancer. It effectively loaded Doxorubicin, a well known anticancer drug, with itself and exhibited prominent citotoxity not only to regular human breast adenocarcinoma cancer cells (MCF 7), but more importantly to doxorubicin-resistant cancer cells. It seems that the inhibition of the lysosomal acidification, resulting in cellular redistribution of the drug to action sites contributes to that.
