Welcome to the Basson lab at King's College London
Our research is aimed at understanding the signalling mechanisms that control morphogenesis of complex structures and organs in the developing embryo and newborn
Signalling and morphogenesis
The precise coordination of the many forces and growth factors acting upon embryonic tissues is required for the development of complex organs. We are interested in how intracellular signalling pathways are regulated during organogenesis. Many cell surface receptors use reversible tyrosine phosphorylation as a means of signal transduction. Studies in a number of biological systems have suggested that these signalling pathways are not merely ON/OFF switches but that subtle differences in signal strength and duration often result in profoundly different outcomes.
The broad aim of our research is to understand how intracellular signaling regulators of the Sprouty family are employed to coordinate morphogenesis of the cerebellum and pharyngeal pouches.