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==Personal Info== | |||
[[Image:davidgmiguez.jpg|160 px|left|David G. Míguez]] | |||
Head of the [http://sysbio.openwetware.org/ Biophysics and Systems Biology Lab ] | |||
Departamento de Física de la Materia Condensada, Universidad Autónoma de Madrid, 28049 Madrid | |||
''Previous Research Institutions'': | |||
*2001-2005 PhD Thesis at Group of Nonlinear Physics at Santiago de Compostela (Galicia, Spain), | |||
*2005-2006 Group of Complex Systems, Brandeis University (MA) | |||
*2006-2009 Department of Systems Biology, Harvard Medical School (MA), | |||
*2009-2011 Instituto de Biología Molecular de Barcelona (CSIC, Spain) | |||
''Background:'' Nonlinear Dynamics, reaction-diffusion, autocatalitic and bistable systems, feedback, pH oscillators, Turing Patterns, Enzyme kinetics, Systems Biology in Cancer, Signaling pathways. | |||
''Interests:'' Systems Biology, Biophysics, Developmental Systems Biology | |||
Editor of [http://www.iospress.nl/journal/in-silico-biology/ In Silico Biology] | |||
==Contact== | |||
David G. Míguez | |||
e-mail: david DOT miguez ''AT'' uam DOT es | |||
Depto. de Fisica de la Materia Condensada | |||
Facultad de Ciencias, Mod 8, 4-13 | |||
Universidad Autonoma de Madrid | |||
Cantoblanco, | |||
28049 Madrid (SPAIN) | |||
phone (+34) 717-711-470 | |||
work (+34) 914-978-076 | |||
==Publications== | |||
= | # D. G. Míguez, ''[http://www.nature.com/articles/srep13265 A Branching Process to Characterize the Dynamics of Stem Cell Differentiation]'', Scientific Reports '''5''', 13265 (2015) | ||
# V. K. Vanag, D.G. Míguez, I. R. Epstein, | # V. Doldán-Martelli & D. G. Míguez, ''[http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117558 Synergistic Interaction between Selective Drugs in Cell Populations Models], PloS one '''10''' (2), e0117558 (2015). | ||
# D.G. Míguez, S. Alonso, A.P. Muñuzuri, F. Sagués, | # A. L. Sanz & D. G. Míguez, ''[http://www.landesbioscience.com/journals/neurogenesis/article/29529/ Dual R-Smads interplay in the regulation of vertebrate neurogenesis]''. Neurogenesis '''1''', e29529 (2014). | ||
# D. G. Míguez, A. P. Muñuzuri, | # T. Ruiz-Herrero, J. Estrada, R. Guantes, D. G. Miguez, ''[http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003274 A tunable coarse-grained model for ligand-receptor interaction]'', PLOS Computational Biology '''9''', e1003274.(2013). | ||
# D. G. Míguez, R. A. Satnoianu, A. P. Muñuzuri, | # D. G. Míguez*, E. Gil-Guiñón, S. Pons and E. Martí ''[http://jcs.biologists.org/content/early/2013/10/08/jcs.130435.abstract Smad2 and Smad3 cooperate and antagonize simultaneously in vertebrate neurogenesis]'', Journal Of Cell Science '''126''', 5335 (2013). '''(*First and corresponding authorship)''' | ||
# D. G. Míguez, M. Dolnik, A. P. Muñuzuri, L. Kramer, | # M. Saade, I. Gutiérrez-Vallejo, G. Le Dréau, M. A. Rabadán, D. G. Miguez, J. Buceta, E. Martí ''[http://www.sciencedirect.com/science/article/pii/S2211124713003306 Sonic hedgehog signaling switches the mode of division in the developing nervous system]'', Cell Reports '''4''',492 (2013). | ||
# D. G. Míguez, G. Izús, A. P. Muñuzuri, | # D. G. Míguez, ''[http://link.springer.com/article/10.1007%2Fs12539-013-0165-x Network Nonlinearities in Drug Treatment]'', Interdisciplinary Sciences: Computational Life Sciences 5,85 (2013). | ||
# D. G. Miguez, V. Perez-Villar, and A. P. Munuzuri, | # P. Gregorio-Godoy, D. G. Míguez, ''[http://digital-library.theiet.org/content/journals/10.1049/iet-syb.2012.0026 Synthetic approaches to study transcriptional networks and noise in mammalian systems]'', IET Systems Biology 7,11 (2013). | ||
# F. Sagués, D. G. Míguez, E. M. Nicola, A. P. Muñuzuri, J. Casademunt, L. Kramer, | # V. Doldán-Martelli, R. Guantes, D. G. Míguez, ''[http://www.nature.com/psp/journal/v2/n2/full/psp20132a.html A Mathematical Model for the Rational Design of Chimeric Ligands in Selective Drug Therapies]'', CPT: Pharmacometrics & Systems Pharmacology '''2''', e26 (2013). | ||
# D. G. Míguez, E. M. Nicola, A. P. Muñuzuri, J. Casademunt, F. Sagués, L. Kramer, | # V. Doldán-Martelli, D. G. Míguez, ''Theoretical Approaches to Growth Hormone Signaling'', in 'Growth Hormones: Synthesis, Regulation and Health Implications', Eds. A. Andersdtr and J. Anderssen Nova Publishers ISBN 9781619426818 (2012). | ||
# M. Kærn, D. G. Míguez, A. P. Muñuzuri, M. Menzinger, | # D. G. Míguez, Milos Dolnik, Irving Epstein and Alberto P. Muñuzuri, ''[http://pre.aps.org/abstract/PRE/v84/i4/e046210 Interaction Of Chemical Patterns in Coupled Layers]'', Phys. Rev. E, '''84''', 046210 (2011). | ||
# B. Peña, C. Pérez-García, A. Sanz-Anchelergues | # D. G. Míguez, ''[http://www.sciencedirect.com/science/article/pii/S0301462210000402 The role of asymmetric binding in ligand-receptor systems with 1:2 interaction ratio]'' Biophys Chem '''148''', 74-81 (2010) | ||
# S. Rüdiger, D. G. Míguez, A. P. Muñuzuri, F. Sagués, J. Casademunt, | # D.G. Míguez, ''Forcing of Nonlinear Pattern Formation Systems'', Lambert Academic Publishing, ISBN 9783838364223 (2010) [http://www.amazon.com/Forcing-Nonlinear-Pattern-Formation-Systems/dp/3838364228 Book]. | ||
# D. G. Míguez, P. McGraw, A. P. Muñuzuri and M. Menzinger, ''[http://pre.aps.org/abstract/PRE/v80/i2/e026208 Selection of Flow-Distributed Oscillation and Turing Patterns by Boundary Forcing in a Linearly Growing, Oscillating Medium]'', Phys. Rev. E, '''80''', 026208 (2009). | |||
# I. A. Swinburne, D. G. Míguez, D. Landgraf, and P. A. Silver, ''[http://genesdev.cshlp.org/content/22/17/2342.full Intron length increases oscillatory periods of gene expression in animal cells]'', Genes & Dev., '''22''' 2008, 2342-2346 (2008). | |||
# S. Alonso, D. G. Míguez, F. Sagués, ''[http://iopscience.iop.org/0295-5075/81/3/30006 Differential susceptibility to noise of mixed Turing and Hopf modes in a photosensitive chemical medium]'', Europhys. Lett, '''81''', 30006 (2008). | |||
# D. G. Míguez, V. K. Vanag, I. R. Epstein, ''[http://www.pnas.org/content/104/17/6992.full Fronts and pulses in an enzymatic reaction with glucose oxidase]'' P.N.A.S. '''104''', 6992 (2007). | |||
# V. K. Vanag, D.G. Míguez, I. R. Epstein, ''[http://jcp.aip.org/resource/1/jcpsa6/v125/i19/p194515_s1 Designing an Enzymatic Oscillator: Bistability and Feedback Control led Oscillations with Glucose Oxidase in a CSTR]'', J. Phys. Chem. '''125''', 194515 (2006). | |||
# D.G. Míguez, S. Alonso, A.P. Muñuzuri, F. Sagués, ''[http://prl.aps.org/abstract/PRL/v97/i17/e178301 Experimental evidence of localized oscillations in the photosensitive chlorine dioxide-iodine-malonic acid reaction]'', Phys. Rev. Lett, '''97''', 178301 (2006). | |||
# D. G. Míguez, A. P. Muñuzuri, ''[http://www.sciencedirect.com/science/article/pii/S0301462206002122 On the orientation of stripes in fish skin patterning]'', Biophys. Chem. '''124''', 161 (2006). | |||
# D. G. Míguez, R. A. Satnoianu, A. P. Muñuzuri, ''[http://pre.aps.org/abstract/PRE/v73/i2/e025201 Experimental steady pattern formation in reaction-diffusion-advection systems]'', Phys. Rev. E '''73''', 025201 (R) (2006). | |||
# D. G. Míguez, M. Dolnik, A. P. Muñuzuri, L. Kramer, ''[http://prl.aps.org/abstract/PRL/v96/i4/e048304 Effect of Axial Growth on Turing Pattern Formation]''. Phys. Rev. Lett '''96''', 048304 (2006). | |||
# D. G. Míguez, G. Izús, A. P. Muñuzuri, ''[http://pre.aps.org/abstract/PRE/v73/i1/e016207 Robustness and Stability of Flow-and-Diffusion Structures]'', Phys. Rev. E '''73''', 016207 (2006). | |||
# D. G. Miguez, V. Perez-Villar, and A. P. Munuzuri, ''[http://pre.aps.org/abstract/PRE/v71/i6/e066217 Turing instability controlled by spatiotemporal imposed dynamics]'', Phys. Rev. E '''71''', 066217 (2005). | |||
# F. Sagués, D. G. Míguez, E. M. Nicola, A. P. Muñuzuri, J. Casademunt, L. Kramer, ''[http://www.sciencedirect.com/science/article/pii/S0167278904003197 Travelling-stripe forcing of Turing patterns]'', Physica D '''199''', 235 (2004). | |||
# D. G. Míguez, E. M. Nicola, A. P. Muñuzuri, J. Casademunt, F. Sagués, L. Kramer, ''[http://prl.aps.org/abstract/PRL/v93/i4/e048303 Traveling-Stripe Forcing Generates Hexagonal Patterns]'', Phys. Rev. Lett. '''93''', 048303 (2004). | |||
# M. Kærn*, D. G. Míguez*, A. P. Muñuzuri, M. Menzinger, ''[http://www.sciencedirect.com/science/article/pii/S030146220400078X Control of chemical pattern formation by a clock-and-wavefront type mechanism]'', Biophys. Chem. '''110''', 231 (2004). '''*Shared 1st authorship'''. | |||
# B. Peña, C. Pérez-García, A. Sanz-Anchelergues, D. G. Míguez, A. P. Muñuzuri, ''[http://pre.aps.org/abstract/PRE/v68/i5/e056206 Transverse instabilities in chemical Turing patterns of stripes]'', Phys. Rev. E '''68''', 056206 (2003). | |||
# S. Rüdiger, D. G. Míguez, A. P. Muñuzuri, F. Sagués, J. Casademunt, ''[http://prl.aps.org/abstract/PRL/v90/i12/e128301 Dynamics of Turing Patterns under Spatiotemporal Forcing]'', Phys. Rev. Lett '''90''', 128301 (2003). | |||
*'''[[User:DavidMiguez|David]] 08:26, 1 September 2015 (EDT)''' |
Revision as of 05:26, 1 September 2015
Personal Info
![David G. Míguez](https://s3-us-west-2.amazonaws.com/oww-files-thumb/c/c8/Davidgmiguez.jpg/160px-Davidgmiguez.jpg)
Head of the Biophysics and Systems Biology Lab
Departamento de Física de la Materia Condensada, Universidad Autónoma de Madrid, 28049 Madrid
Previous Research Institutions:
- 2001-2005 PhD Thesis at Group of Nonlinear Physics at Santiago de Compostela (Galicia, Spain),
- 2005-2006 Group of Complex Systems, Brandeis University (MA)
- 2006-2009 Department of Systems Biology, Harvard Medical School (MA),
- 2009-2011 Instituto de Biología Molecular de Barcelona (CSIC, Spain)
Background: Nonlinear Dynamics, reaction-diffusion, autocatalitic and bistable systems, feedback, pH oscillators, Turing Patterns, Enzyme kinetics, Systems Biology in Cancer, Signaling pathways.
Interests: Systems Biology, Biophysics, Developmental Systems Biology
Editor of In Silico Biology
Contact
David G. Míguez
e-mail: david DOT miguez AT uam DOT es
Depto. de Fisica de la Materia Condensada Facultad de Ciencias, Mod 8, 4-13 Universidad Autonoma de Madrid Cantoblanco, 28049 Madrid (SPAIN)
phone (+34) 717-711-470 work (+34) 914-978-076
Publications
- D. G. Míguez, A Branching Process to Characterize the Dynamics of Stem Cell Differentiation, Scientific Reports 5, 13265 (2015)
- V. Doldán-Martelli & D. G. Míguez, Synergistic Interaction between Selective Drugs in Cell Populations Models, PloS one 10 (2), e0117558 (2015).
- A. L. Sanz & D. G. Míguez, Dual R-Smads interplay in the regulation of vertebrate neurogenesis. Neurogenesis 1, e29529 (2014).
- T. Ruiz-Herrero, J. Estrada, R. Guantes, D. G. Miguez, A tunable coarse-grained model for ligand-receptor interaction, PLOS Computational Biology 9, e1003274.(2013).
- D. G. Míguez*, E. Gil-Guiñón, S. Pons and E. Martí Smad2 and Smad3 cooperate and antagonize simultaneously in vertebrate neurogenesis, Journal Of Cell Science 126, 5335 (2013). (*First and corresponding authorship)
- M. Saade, I. Gutiérrez-Vallejo, G. Le Dréau, M. A. Rabadán, D. G. Miguez, J. Buceta, E. Martí Sonic hedgehog signaling switches the mode of division in the developing nervous system, Cell Reports 4,492 (2013).
- D. G. Míguez, Network Nonlinearities in Drug Treatment, Interdisciplinary Sciences: Computational Life Sciences 5,85 (2013).
- P. Gregorio-Godoy, D. G. Míguez, Synthetic approaches to study transcriptional networks and noise in mammalian systems, IET Systems Biology 7,11 (2013).
- V. Doldán-Martelli, R. Guantes, D. G. Míguez, A Mathematical Model for the Rational Design of Chimeric Ligands in Selective Drug Therapies, CPT: Pharmacometrics & Systems Pharmacology 2, e26 (2013).
- V. Doldán-Martelli, D. G. Míguez, Theoretical Approaches to Growth Hormone Signaling, in 'Growth Hormones: Synthesis, Regulation and Health Implications', Eds. A. Andersdtr and J. Anderssen Nova Publishers ISBN 9781619426818 (2012).
- D. G. Míguez, Milos Dolnik, Irving Epstein and Alberto P. Muñuzuri, Interaction Of Chemical Patterns in Coupled Layers, Phys. Rev. E, 84, 046210 (2011).
- D. G. Míguez, The role of asymmetric binding in ligand-receptor systems with 1:2 interaction ratio Biophys Chem 148, 74-81 (2010)
- D.G. Míguez, Forcing of Nonlinear Pattern Formation Systems, Lambert Academic Publishing, ISBN 9783838364223 (2010) Book.
- D. G. Míguez, P. McGraw, A. P. Muñuzuri and M. Menzinger, Selection of Flow-Distributed Oscillation and Turing Patterns by Boundary Forcing in a Linearly Growing, Oscillating Medium, Phys. Rev. E, 80, 026208 (2009).
- I. A. Swinburne, D. G. Míguez, D. Landgraf, and P. A. Silver, Intron length increases oscillatory periods of gene expression in animal cells, Genes & Dev., 22 2008, 2342-2346 (2008).
- S. Alonso, D. G. Míguez, F. Sagués, Differential susceptibility to noise of mixed Turing and Hopf modes in a photosensitive chemical medium, Europhys. Lett, 81, 30006 (2008).
- D. G. Míguez, V. K. Vanag, I. R. Epstein, Fronts and pulses in an enzymatic reaction with glucose oxidase P.N.A.S. 104, 6992 (2007).
- V. K. Vanag, D.G. Míguez, I. R. Epstein, Designing an Enzymatic Oscillator: Bistability and Feedback Control led Oscillations with Glucose Oxidase in a CSTR, J. Phys. Chem. 125, 194515 (2006).
- D.G. Míguez, S. Alonso, A.P. Muñuzuri, F. Sagués, Experimental evidence of localized oscillations in the photosensitive chlorine dioxide-iodine-malonic acid reaction, Phys. Rev. Lett, 97, 178301 (2006).
- D. G. Míguez, A. P. Muñuzuri, On the orientation of stripes in fish skin patterning, Biophys. Chem. 124, 161 (2006).
- D. G. Míguez, R. A. Satnoianu, A. P. Muñuzuri, Experimental steady pattern formation in reaction-diffusion-advection systems, Phys. Rev. E 73, 025201 (R) (2006).
- D. G. Míguez, M. Dolnik, A. P. Muñuzuri, L. Kramer, Effect of Axial Growth on Turing Pattern Formation. Phys. Rev. Lett 96, 048304 (2006).
- D. G. Míguez, G. Izús, A. P. Muñuzuri, Robustness and Stability of Flow-and-Diffusion Structures, Phys. Rev. E 73, 016207 (2006).
- D. G. Miguez, V. Perez-Villar, and A. P. Munuzuri, Turing instability controlled by spatiotemporal imposed dynamics, Phys. Rev. E 71, 066217 (2005).
- F. Sagués, D. G. Míguez, E. M. Nicola, A. P. Muñuzuri, J. Casademunt, L. Kramer, Travelling-stripe forcing of Turing patterns, Physica D 199, 235 (2004).
- D. G. Míguez, E. M. Nicola, A. P. Muñuzuri, J. Casademunt, F. Sagués, L. Kramer, Traveling-Stripe Forcing Generates Hexagonal Patterns, Phys. Rev. Lett. 93, 048303 (2004).
- M. Kærn*, D. G. Míguez*, A. P. Muñuzuri, M. Menzinger, Control of chemical pattern formation by a clock-and-wavefront type mechanism, Biophys. Chem. 110, 231 (2004). *Shared 1st authorship.
- B. Peña, C. Pérez-García, A. Sanz-Anchelergues, D. G. Míguez, A. P. Muñuzuri, Transverse instabilities in chemical Turing patterns of stripes, Phys. Rev. E 68, 056206 (2003).
- S. Rüdiger, D. G. Míguez, A. P. Muñuzuri, F. Sagués, J. Casademunt, Dynamics of Turing Patterns under Spatiotemporal Forcing, Phys. Rev. Lett 90, 128301 (2003).
- David 08:26, 1 September 2015 (EDT)