Dahlquist:Evo-Ed Evolution of Lactase Persistence

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This page contains notes from the BioQUEST Curriculumm Consortium Summer Workshop 2015 project on the Evo-Ed Case: The Evolution of Lactase Persistence.

Bibliography and Links

• Stegmann, A., Hansen, M., Wang, Y., Larsen, J. B., Lund, L. R., Ritié, L., ... & Olsen, J. (2006). Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation. Physiological genomics, 27(2), 141-155.
  • Link to database of mouse enterocyte expression data
  • BUT the gene encoding Lactase-phlorizin hydrolase was not on the Affy chip in this dataset.
• Troelsen, J., Mitchelmore, C., Spodsberg, N., Jensen, A., Noren, O., & Sjostrom, H. (1997). Regulation of lactase–phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2. Biochem. J, 322, 833-838.
• Fang, R., Santiago, N. A., Olds, L. C., & Sibley, E. (2000). The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation. Gastroenterology, 118(1), 115-127.
  • behind paywall
• Troelsen, J. T. (2005). Adult-type hypolactasia and regulation of lactase expression. Biochimica et Biophysica Acta (BBA)-General Subjects, 1723(1), 19-32.
  • behind paywall
• Lactose Intolerance and Health, Evidence Reports/Technology Assessments, No. 192, Investigators: Timothy J Wilt, MD, MPH, Aasma Shaukat, MD, MPH, Tatyana Shamliyan, MD, MS, Brent C Taylor, PhD, MPH, Roderick MacDonald, MS, James Tacklind, BS, Indulis Rutks, BS, Sarah Jane Schwarzenberg, MD, Robert L Kane, MD, and Michael Levitt, MD.
• Boyd, M., Bressendorff, S., Møller, J., Olsen, J., & Troelsen, J. T. (2009). Mapping of HNF4α target genes in intestinal epithelial cells. BMC gastroenterology, 9(1), 68.
• Mattar, R., de Campos Mazo, D. F., & Carrilho, F. J. (2012). Lactose intolerance: diagnosis, genetic, and clinical factors. Clinical and experimental gastroenterology, 5, 113.
• Olds, L. C., Ahn, J. K., & Sibley, E. (2011). − 13915* G DNA polymorphism associated with lactase persistence in Africa interacts with Oct-1. Human genetics, 129(1), 111-113.
• Lewinsky, R. H., Jensen, T. G., Møller, J., Stensballe, A., Olsen, J., & Troelsen, J. T. (2005). T− 13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro. Human molecular genetics, 14(24), 3945-3953.
• http://www.ncbi.nlm.nih.gov/pubmed/14990752
• OCT-1 Gene Regulatory Network in Human
• LCT gene page in NCBI gene database
• OCT-1 structures