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In the press
Nature Methods Research Highlights article on "Network countdown" August 2009 [1]
Wall Street Journal article on "Programming cells to do the work" July 2009 [2]
Jim Collins' Nature Journal Club article on "A bioengineer gets schooled by E. coli" July 2009
Nature Biotechnology Research Highlights article on "Making cells count" July 2009
Nature Chemical Biology Research Highlights article on "Easy as 1,2,3" July 2009
Jim Collins on BBC's Americana July 2009
Christian Science Monitor article on "Scientists turn living cells into clocks" June 2009
Discovery Channel story on "Bacteria cells programmed to count" June 2009
Science News article on "Engineeered DNA counts it out" May 2009
New Scientist article on "Counting cells could trigger their own destruction" May 2009
Wired Science article on "Cellular counter brings computer programming to life" May 2009
Science Perspective article on "It's the DNA that counts" May 2009
MIT news story on "Engineered circuits can count cellular events" May 2009
Nature Reviews Genetic Research Highlights article on "Towards off-the-shelf networks" May 2009
Nature Biotechnology News & Views article on "Overpowering the component problem" May 2009
Genetic Engineering & Biotechnology News article on "Practical applications of systems biology" May 2009
Technology Review article on "Brewing with synthetic biology" April 2009
The Scientist article on "Plug and play genes" April 2009
Jim Collins on NPR's Science Friday with Ira Flatow April 2009
HHMI News Story on "Plug and play comes to synthetic biology" April 2009
Nature Biotechnology Research Highlights article on "Engineered phage foil antibiotic resistance" April 2009
Focus article on "Bacterial viruses boost antibiotic action" April 2009
Jim Collins on NPR's Science Friday with Ira Flatow March 2009
Nature news story on "Engineered viruses fight bacteria" March 2009
MIT news story on "Engineered viruses can help fight antibiotic resistance" March 2009
Discovery Tech: "How would you explain synthetic biology to Darwin?" February 2009
Nature Chemical Biology Research Highlights article on "Antibiotics do double time" January 2009
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Technical
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Our lab is focused on developing and using nonlinear dynamics approaches to study, mimic and improve the function of biological systems. We are currently working in three areas:
Systems Biology: We are developing and implementing computational-experimental methods to reverse engineer and analyze regulatory networks in microbes and higher organisms.
Synthetic Biology: We are modeling and building synthetic gene networks for a variety of biotechnology and biocomputing applications. We are also using engineered gene networks to study general principles underlying gene regulation.
Noise-Enhanced Sensorimotor Function: We are developing noise-based devices, such as vibrating insoles, to improve balance control in older adults and patients with diabetic neuropathy, stroke, Parkinson's disease, and multiple sclerosis, respectively.
Our lab is part of the Center for BioDynamics [3], the Department of Biomedical Engineering [4], the Bioinformatics Program, the Center for Advanced Biotechnology, the Molecular Biology, Cell Biology & Biochemistry (MCBB) Program at Boston University, and the Frontiers in Integrative Biological Research.
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