CH391L/S2013/SuggestedTopics
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Topics
Us this page to brainstorm or suggest possible topics and ideas
Topic choices should be discussed with the instructor at least one week prior to the scheduled presentation. A list of topics can be found below, but there is significant leeway to tailor the papers and topics toward your specific interests.
Double Strand Break (DSB) Repair
- DSB repair mechanisms in prokaryotes
- Homologous Recombination
- SOS Response
- DSB repair in eukaryotes
- Homologous Recombination
- Non-Homologous End Joining
- Alternative End-Joining
- DSB Repair: Pathway Choice
- DSB-related diseases:
- Seckel & Jawad Syndromes
- Nijmegen Breakage Syndrome
- Ataxia - telangiectasia
- Werner & Bloom Syndromes
DNA Replication and Genomic Instability
- Replicating Aberrant Structures
- DNA Hairpins
- Z-DNA
- G-Quadruplex DNA
- Chromosome Fragile Sites
- Replication-Transcription Conflicts
- Replication-Collapse at Interstrand Cross Links
Mechanisms of DNA Mismatch Repair
- Mismatch Repair in Prokaryotes
- Very short patch repair
- Mismatch Repair in Eukaryotes
- How is a Mismatch Recognized?
- How is a Mismatch Removed?
- Mismatch repair and adaptation
- Mutagenesis in Bacteria
- Mutagenesis in Eukaryotes
- Meiotic-specific Roles of Mismatch Repair Proteins
- Diseases
- Lynch Syndrome
Mitochondrial DNA Damage
- Structure of Mitochondrial DNA
- Mechanisms of DNA Repair
- Mitochondrial DNA repair and aging
- Diseases Associated with Mitochondrial DNA Damage
Nucleotide Excision Repair
Base Excision Repair
Damage Tolerance and Mutagenesis
- Prokaryotes
- Error-prone translesion synthesis
- Living with chronic damage
- Eukaryotes
- Error-prone translesion synthesis
- Living with chronic damage
Cell-cycle response to DNA damage
Systems approaches to cancer research
- Global analysis of transcription changes
- Global analysis of siRNA changes in cancer cells