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biomineralization <br>
biomineralization <br>
lab grown meat/organs <br>
lab grown meat/organs <br>
cell printing/scaffolding <br>
cell printing/scaffolding (Evan)<br>
genetic circuits <br>
=== ''In vitro'' Biology ===
=== ''In vitro'' Biology ===
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===Genetic Circuits===
Stuff like oscillators,double negative genetic circuits, etc.
== Other ==
== Other ==
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=== Notable iGEM Projects ===
=== Notable iGEM Projects ===
=== Ideas for next time ===
* Stochasticity / Noise

Current revision

This is a brainstorming page...


What is synthetic biology?


Imperial College iGEM team documentary (50 min)

E. chromi

Recent/Upcoming Meetings

New Topics

Synthetic Biology Part II

Algae/Biofuels (aurko)
DNA computation/fabrication (Tyler)
Spider goats
CRISPR genome editing (Ben)
gas vesicles
dental probiotics (Al)
mussel protein bioadhesive
metabolic engineering
molecular gastronomy
lab grown meat/organs
cell printing/scaffolding (Evan)
genetic circuits

In vitro Biology

Validation of an entirely in vitro approach for rapid prototyping of DNA regulatory elements for synthetic biology[1]

  1. Chappell J, Jensen K, and Freemont PS. . pmid:23371936. PubMed HubMed [invitro]
    Using cell-free extracts of E. coli to eliminate transformation/selection/culturing/purification steps when testing new DNA parts and genetic circuits. Additionally, In vitro performance of the tested parts had a clear correlation to in vivo performance.

Algal biofuels

DNA computation / nanomachines

  1. Ausländer S, Ausländer D, Müller M, Wieland M, and Fussenegger M. . pmid:22722847. PubMed HubMed [Langecker]
    Programmable single-cell mammalian biocomputers

  2. Langecker M, Arnaut V, Martin TG, List J, Renner S, Mayer M, Dietz H, and Simmel FC. . pmid:23161995. PubMed HubMed [Langecker]
    DNA origami to design functional structures

All Medline abstracts: PubMed HubMed

Spider Goats

"Spider Goats" - synthetic silk production. Video -

Pathogen synthesis

  1. Cello J, Paul AV, and Wimmer E. . pmid:12114528. PubMed HubMed [Cello2002]
    Polio virus

  2. Herfst S, Schrauwen EJ, Linster M, Chutinimitkul S, de Wit E, Munster VJ, Sorrell EM, Bestebroer TM, Burke DF, Smith DJ, Rimmelzwaan GF, Osterhaus AD, and Fouchier RA. . pmid:22723413. PubMed HubMed [Herfst2012]
    AIrborne H5N1

  3. Russell CA, Fonville JM, Brown AE, Burke DF, Smith DL, James SL, Herfst S, van Boheemen S, Linster M, Schrauwen EJ, Katzelnick L, Mosterín A, Kuiken T, Maher E, Neumann G, Osterhaus AD, Kawaoka Y, Fouchier RA, and Smith DJ. . pmid:22723414. PubMed HubMed [Russell2012]
    AIrborne H5N1

All Medline abstracts: PubMed HubMed

Airborne H5N1 publication debate

Riboswitches / Aptamer Biosensors

  1. Davidson ME, Harbaugh SV, Chushak YG, Stone MO, and Kelley-Loughnane N. . pmid:23092157. PubMed HubMed [Russell2012]
    DNT/TNT riboswitch

  2. Ehrentreich-Förster E, Orgel D, Krause-Griep A, Cech B, Erdmann VA, Bier F, Scheller FW, and Rimmele M. . pmid:18504560. PubMed HubMed [Ehrentreich2008]
    TNT aptamer

  3. Stojanovic MN, de Prada P, and Landry DW. . pmid:11457319. PubMed HubMed [Stojanovic2001]
    Cocaine aptamer biosensor

  4. Stojanovic MN and Landry DW. . pmid:12175205. PubMed HubMed [Stojanovic2002]
    Cocaine aptamer biosensor, next iteration

All Medline abstracts: PubMed HubMed

Gene Therapy

Spermless Mosquitos Mate without Offspring

  1. Thailayil J, Magnusson K, Godfray HC, Crisanti A, and Catteruccia F. . pmid:21825136. PubMed HubMed [Thailayil2011]

Mussel bioadhesives

Dental Probiotics

  1. Hillman JD. . pmid:12369203. PubMed HubMed [Russell2012]
    Genetically modified Streptococcus mutans for the prevention of dental caries


Asilomar:This likely fits into some ethics section. But would be useful to get a nice, reasonably detailed overview of this conference. It is referenced often in synthetic biology circles as a model for public disclosure and internal consistency within a field. Would be nice to understand where/how the analogy fits and maybe where it doesn't?


  1. Moe-Behrens GH, Davis R, and Haynes KA. . pmid:23355834. PubMed HubMed [Moe-Behrens2013]
    Preparing synthetic biology for the world

CRISPR Genome Editing

Papers described here

Gas Vesicles

Would be a new topic no one has chosen before.

Topic Updates


  1. Temme K, Zhao D, and Voigt CA. . pmid:22509035. PubMed HubMed [Temme2012]
    Refactoring Nitrogen fixation gene cluster

Ancestral Sequence Reconstruction

Genetic Circuits

Stuff like oscillators,double negative genetic circuits, etc.




Other synthetic biology courses

Notable iGEM Projects

Ideas for next time

  • Stochasticity / Noise
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