CH391L/S13/Phage Therapy

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==History==
==History==
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The discovery of the "bacteriophage phenomenon" occurred independently over a span of twenty years:
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The discovery of a heat-labile, bacteria-killing substance that could pass through extremely small filters was discovered several times:
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| 1915|| d'Herelle, French-Canadian, ''Shigella''. Coined the term "bacteriophage".
| 1915|| d'Herelle, French-Canadian, ''Shigella''. Coined the term "bacteriophage".
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The first therapeutic usage of phage was in 1919, to treat a child with severe dysentery. In a classic case of old-school science, the lead researchers (which included d'Herelle) drank portions of the bacteriophage preparation the day before treating the child, to check the treatment's safety in humans. The child fully recovered within a few days, and further tests confirmed the result.
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In the 1930s and 1940s, bacteriophage preparations were developed and sold by L'Oréal and the Eli Lilly Company. The development and mass production of antibiotics in the late 1940s halted research into phage therapy in the West, due to the superior efficacy and simplicity of antibiotics.
==Current Applications==
==Current Applications==

Revision as of 17:26, 23 March 2013

Contents

Introduction to Phage Therapy

History

The discovery of a heat-labile, bacteria-killing substance that could pass through extremely small filters was discovered several times:

Year Event
1896 Hankin, British bacteriologist working on Vibrio cholerae
1898 Gamaleya, Russian, Bacillus subtilis
1915 Twort, British, Staphylococcus
1915 d'Herelle, French-Canadian, Shigella. Coined the term "bacteriophage".

The first therapeutic usage of phage was in 1919, to treat a child with severe dysentery. In a classic case of old-school science, the lead researchers (which included d'Herelle) drank portions of the bacteriophage preparation the day before treating the child, to check the treatment's safety in humans. The child fully recovered within a few days, and further tests confirmed the result.

In the 1930s and 1940s, bacteriophage preparations were developed and sold by L'Oréal and the Eli Lilly Company. The development and mass production of antibiotics in the late 1940s halted research into phage therapy in the West, due to the superior efficacy and simplicity of antibiotics.

Current Applications

IGEM

References

  1. []
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