CH391L/S13/Optogenetics: Difference between revisions
From OpenWetWare
Jump to navigationJump to search
| Line 41: | Line 41: | ||
#Zemelman2002 pmid=11779476 | #Zemelman2002 pmid=11779476 | ||
#Lalumiere2011 pmid=21255749 | #Lalumiere2011 pmid=21255749 | ||
#Doroudchi2011 pmid=21505421 | |||
</biblio> | </biblio> | ||
Revision as of 22:51, 24 February 2013
Introduction to Optogenetics
"Before we can find the answers, we need the power to ask new questions." -Karl Deisseroth
History
"The brain is a world consisting of a number of unexplored continents and great stretches of unknown territory." - Santiago Ramón y Cajal
Biochemistry behind Optogenetics
The Optogenetic Process
Gene Delivery
Controlled Illumination
Applications of Optogenetics
Neuroscience
Cardiology: Pacemakers
Hepatology: Diabetes and Beta Cells
IGEM Take-home Message
http://2012.igem.org/Team:Washington/Optogenetics http://2006.igem.org/wiki/index.php/University_of_Texas_2006 http://2006.igem.org/wiki/index.php/UT_Austin_2005 http://2004.igem.org/austin.cgi
References
- Mei Y and Zhang F. Molecular tools and approaches for optogenetics. Biol Psychiatry. 2012 Jun 15;71(12):1033-8. DOI:10.1016/j.biopsych.2012.02.019 |
- Yizhar O, Fenno L, Zhang F, Hegemann P, and Diesseroth K. Microbial opsins: a family of single-component tools for optical control of neural activity. Cold Spring Harb Protoc. 2011 Mar 1;2011(3):top102. DOI:10.1101/pdb.top102 |
- Zemelman BV, Lee GA, Ng M, and Miesenböck G. Selective photostimulation of genetically chARGed neurons. Neuron. 2002 Jan 3;33(1):15-22. DOI:10.1016/s0896-6273(01)00574-8 |
- LaLumiere RT. A new technique for controlling the brain: optogenetics and its potential for use in research and the clinic. Brain Stimul. 2011 Jan;4(1):1-6. DOI:10.1016/j.brs.2010.09.009 |
- Doroudchi MM, Greenberg KP, Liu J, Silka KA, Boyden ES, Lockridge JA, Arman AC, Janani R, Boye SE, Boye SL, Gordon GM, Matteo BC, Sampath AP, Hauswirth WW, and Horsager A. Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness. Mol Ther. 2011 Jul;19(7):1220-9. DOI:10.1038/mt.2011.69 |
