CH391L/S13/Optogenetics: Difference between revisions

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#Yizhar2011 pmid=18612302
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#Zemelman2002 pmid=11779476
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Revision as of 21:09, 24 February 2013

Introduction to Optogenetics

"Before we can find the answers, we need the power to ask new questions." -Karl Deisseroth

History

"The brain is a world consisting of a number of unexplored continents and great stretches of unknown territory." - Santiago Ramón y Cajal

Biochemistry behind Optogenetics

The Optogenetic Process

Gene Delivery

Controlled Illumination

Applications of Optogenetics

Neuroscience

Cardiology: Pacemakers

Hepatology: Diabetes and Beta Cells

IGEM Take-home Message

http://2012.igem.org/Team:Washington/Optogenetics http://2006.igem.org/wiki/index.php/University_of_Texas_2006 http://2006.igem.org/wiki/index.php/UT_Austin_2005 http://2004.igem.org/austin.cgi

References

  1. Mei Y and Zhang F. Molecular tools and approaches for optogenetics. Biol Psychiatry. 2012 Jun 15;71(12):1033-8. DOI:10.1016/j.biopsych.2012.02.019 | PubMed ID:22480664 | HubMed [Mei2012]
  2. Canton B, Labno A, and Endy D. Refinement and standardization of synthetic biological parts and devices. Nat Biotechnol. 2008 Jul;26(7):787-93. DOI:10.1038/nbt1413 | PubMed ID:18612302 | HubMed [Yizhar2011]
  3. Zemelman BV, Lee GA, Ng M, and Miesenböck G. Selective photostimulation of genetically chARGed neurons. Neuron. 2002 Jan 3;33(1):15-22. DOI:10.1016/s0896-6273(01)00574-8 | PubMed ID:11779476 | HubMed [Zemelman2002]

All Medline abstracts: PubMed | HubMed