CH391L/S13/Mechanosensing: Difference between revisions
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*Osmotic pressure, resulting from a difference in solute concentrations across a semi-permeable membrane | *Osmotic pressure, resulting from a difference in solute concentrations across a semi-permeable membrane | ||
High hydrostatic pressure (HHP) can cause dissociation of multimeric proteins, decreased membrane fluidity, and and unfolding of monomeric proteins in extreme cases [biotech review]. | High hydrostatic pressure (HHP) can cause dissociation of multimeric proteins, decreased membrane fluidity, and and unfolding of monomeric proteins in extreme cases [biotech review]. | ||
In some cases, changes in mechanical stress result in differential gene expression driven by mechanosensitive promoters or repressors. Genes that have increased expression might include cold- and heat-shock and other stress response proteins, barostable synthases [vezzi ref?], or | In some cases, changes in mechanical stress result in differential gene expression driven by mechanosensitive promoters or repressors. Genes that have increased expression might include cold- and heat-shock and other stress response proteins, barostable synthases [vezzi ref?], or transporter proteins[add reference]. Downregulated genes might include ______. In other cases, porin proteins which provide ion diffusion pathways are opened in response to osmotic stress across the membrane. | ||
==Mechanosensitive Promoters== | ==Mechanosensitive Promoters== |
Revision as of 10:55, 8 April 2013
Introduction
Mechanosensing refers to the ability of an organism to respond to changes in mechanical force on them or their environment. The mechanical stress can be in a variety of forms:
- Hydrostatic pressure, as in the case of deep ocean environments
- Fluid shear stress, as in the case of blood flowing through veins
- Direct force, as in the case of body weight on a bone
- Osmotic pressure, resulting from a difference in solute concentrations across a semi-permeable membrane
High hydrostatic pressure (HHP) can cause dissociation of multimeric proteins, decreased membrane fluidity, and and unfolding of monomeric proteins in extreme cases [biotech review]. In some cases, changes in mechanical stress result in differential gene expression driven by mechanosensitive promoters or repressors. Genes that have increased expression might include cold- and heat-shock and other stress response proteins, barostable synthases [vezzi ref?], or transporter proteins[add reference]. Downregulated genes might include ______. In other cases, porin proteins which provide ion diffusion pathways are opened in response to osmotic stress across the membrane.