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Lee EH, Byrn SR, Pinal R. [http://www.ncbi.nlm.nih.gov/pubmed/22972701 The solution properties of mefenamic acid and a closely related analogue are indistinguishable in polar solvents but significantly different in nonpolar environments.] J'' Pharm Sci'' 2012 Dec;101(12):4529-39. doi: 10.1002/jps.23316. Epub 2012 Sep 12.
<h2>Recent Publications</h2>
http://www.ncbi.nlm.nih.gov/pubmed/?term=byrn%2C+stephen+r


Trasi NS, Byrn SR. [http://www.ncbi.nlm.nih.gov/pubmed/22585375 Mechanically induced amorphization of drugs: a study of the thermal behavior of cryomilled compounds.] ''AAPS PharmSciTech'' 2012 Sep;13(3):772-84. doi: 10.1208/s12249-012-9801-8. Epub 2012 May 15.  [PubMed - in process]
<ol type="1">


Weber RJ, Benmore CJ, Tumber SK, Tailor AN, Rey CA, Taylor LS, Byrn SR. [http://www.ncbi.nlm.nih.gov/pubmed/22038123 Acoustic levitation: recent developments and emerging opportunities in biomaterials research.] ''Eur Biophys J'' 2012 Apr;41(4):397-403. doi: 10.1007/s00249-011-0767-3. Epub 2011 Oct 30.
<li>Fortunak, J.; Byrn, S.R.; Dyson, B.; Ekeocha, Z.; Ellison, T.; King, C.L.; Kulkarni, A.A.; Lee, M.; Conrad, C.; Thompson, K., [http://www.ajol.info/index.php/tjpr/article/view/95952 An efficient, green chemical synthesis of the malaria drug, piperaquine], <em>Tropical Journal of Pharmaceutical Research</em> (2013), 12(5), 791-798.</li>


Su Z, Luthra S, Krzyzaniak JF, Agra-Kooijman DM, Kumar S, Byrn SR, Shalaev EY. [http://www.ncbi.nlm.nih.gov/pubmed/21721005 Crystalline, liquid crystalline, and isotropic phases of sodium deoxycholate in water.] ''J Pharm Sci'' 2011 Nov;100(11):4836-44. doi: 10.1002/jps.22690. Epub 2011 Jun 30.
<li>Lee, J.; Boerrigter, S.X.M.; Jung, Y.W.; Byun, Y.; Yuk, S.H.; Byrn, S.R.; Lee, E.H, [http://www.sciencedirect.com/science/article/pii/S0928098713002583 Organic vapor sorption method of isostructural solvates and polymorph of tenofovir disoproxil fumarate,] <em>European Journal of Pharmaceutical Sciences</em> (2013), 50(3-4), 253-262.</li>


Byrn SR, Tishmack PA, Milton MJ, van de Velde H. [http://www.ncbi.nlm.nih.gov/pubmed/21455817 Analysis of two commercially available bortezomib products: differences in assay of active agent and impurity profile.] AA''PS PharmSciTech'' 2011 Jun;12(2):461-7. Epub 2011 Apr 1.
<li>Weber, J.K.R.; Benmore, C.J.; Tailor, A.N.; Tumber, S.K.; Neuefeind, J.; Cherry, B.; Yarger, J.L.; Mou, Q.; Weber, W.; Byrn, S.R. [http://www.sciencedirect.com/science/article/pii/S0301010413002437 A neutron-X-ray, NMR and calorimetric study of glassy Probucol synthesized using containerless techniques,] <em>Chemical Physics</em> (2013), 424, 89-92.</li>


Lee, Eun Hee; Boerrigter, Stephan X. M.; Byrn, Stephen R. [http://pubs.acs.org/doi/abs/10.1021/cg900549h Epitaxy of a Structurally Related Compound on the (100) Faces of Flufenamic Acid Form I and III Single Crystals.] ''Crystal Growth & Design'' 2010;10(2):518–527. doi: 10.1021/cg900549h. Epub January 8, 2010
<li>Benmore, C.J.; Weber, J.K.R.; Tailor, A.N.; Cherry, B.R.; Yarger, J.L.; Mou, Q.; Weber, W.; Neuefeind, J.; Byrn, S.R., [http://www.ncbi.nlm.nih.gov/pubmed/?term=Structural+characterization+and+aging+of+glassy+pharmaceuticals+made+using+acoustic+levitation Structural characterization and aging of glassy pharmaceuticals made using acoustic levitation,] <em>Journal of Pharmaceutical Sciences</em> (2013), 102(4), 1290-1300.</li>


Ito, Takanori; Byrn, Stephen; Chen, Xin; Carvajal, M. Teresa. [http://www.ncbi.nlm.nih.gov/pubmed?term=Thermal%20insight%20of%20mechanically%20activated%20bile%20acid%20powders%2C Thermal insight of mechanically activated bile acid powders.] ''Int J Pharm.'' 2011 Nov 25;420(1), 68-75.
<li>Gurvich, V.J; Byrn, S.R., [http://www.ncbi.nlm.nih.gov/pubmed/?term=NIPTE%3A+a+multi-university+partnership+supporting+academic+drug+development NIPTE: a multi-university partnership supporting academic drug development,] <em>Drug Discovery Today</em> (2013), 18(19-20), 916-21.


Emeje, Martins; Isimi, Christiana; Byrn, Stephen; Fortunak, Joseph; Kunle, Olobayo; Ofoefule, Sabinus. [http://ijpr.sbmu.ac.ir/?_action=articleInfo&article=971 Extraction and physicochemical characterization of a new polysaccharide obtained from the fresh fruits of Abelmoschus esculentus.] ''Iranian Journal of Pharmaceutical Research'' 2011; 10(2):237-246.
<li>Byrn, Stephen R, and Henck, Jan-Olav. [http://www.sciencedirect.com/science/article/pii/S1740674912000194 Optimizing Physical Form – opportunities and limitations.] <em>Drug Discovery Today: Technologies</em> 2012; 9(2): e73-e78.</li>


Byrn, Stephen R.; Tishmack, Patrick A.; Milton, Mark J.; Velde, Helgi. [http://www.ncbi.nlm.nih.gov/pubmed?term=Analysis%20of%20Two%20Commercially%20Available%20Bortezomib%20Products%3A%20Differences%20in%20Assay%20of%20Active%20Agent%20and%20Impurity%20Profile. Analysis of Two Commercially Available Bortezomib Products: Differences in Assay of Active Agent and Impurity Profile.] ''AAPS PharmSciTech'' 2011 Jun;12(2):461-7. Epub 2011 Apr 1.
<li>Lee EH, Byrn SR, Pinal R. [http://www.ncbi.nlm.nih.gov/pubmed/22972701 The solution properties of mefenamic acid and a closely related analogue are indistinguishable in polar solvents but significantly different in nonpolar environments.] J'' Pharm Sci'' 2012 Dec;101(12):4529-39. doi: 10.1002/jps.23316. Epub 2012 Sep 12.</li>


Yamauchi, Masahiro; Lee, Eun Hee; Otte, Andrew; Byrn, Stephen R.; Carvajal, M. Teresa. [http://http://pubs.acs.org/doi/abs/10.1021/cg101098v?prevSearch=Contrasting%2Bthe%2BSurface%2Band%2BBulk%2BProperties%2Bof%2BAnhydrate%2Band%2BDehydrated%2BHydrate%2BMaterials&searchHistoryKey= Contrasting the Surface and Bulk Properties of Anhydrate and Dehydrated Hydrate Materials.] ''Crystal Growth & Design'' 2011;11(3):692-698.  
<li>Trasi NS, Byrn SR. [http://www.ncbi.nlm.nih.gov/pubmed/22585375 Mechanically induced amorphization of drugs: a study of the thermal behavior of cryomilled compounds.] ''AAPS PharmSciTech'' 2012 Sep;13(3):772-84. doi: 10.1208/s12249-012-9801-8. Epub 2012 May 15. [PubMed - in process]</li>


Trasi, Niraj S.; Boerrigter, Stephan X. M.; Byrn, Stephen R.; Carvajal, Teresa M. [http://www.sciencedirect.com/science/article/pii/S0378517311000160 Investigating the effect of dehydration conditions on the compactibility of glucose.] ''Int J Pharm'' 2011;406(1-2):55-61.  
<li>Weber RJ, Benmore CJ, Tumber SK, Tailor AN, Rey CA, Taylor LS, Byrn SR. [http://www.ncbi.nlm.nih.gov/pubmed/22038123 Acoustic levitation: recent developments and emerging opportunities in biomaterials research.] ''Eur Biophys J'' 2012 Apr;41(4):397-403. doi: 10.1007/s00249-011-0767-3. Epub 2011 Oct 30.</li>


Mao, Chen; Prasanth Chamarthy, Sai; Byrn, Stephen R.; Pinal, Rodolfo. [http://http://www.ncbi.nlm.nih.gov/pubmed?term=Theoretical%20and%20Experimental%20Considerations%20on%20the%20Enthalpic%20Relaxation%20of%20Organic%20Glasses%20using%20Differential%20Scanning%20Calorimetry. Theoretical and Experimental Considerations on the Enthalpic Relaxation of Organic Glasses using Differential Scanning Calorimetry.] ''Journal of Physical Chemistry B'' 2010;114(1):269-279.  
<li>Su Z, Luthra S, Krzyzaniak JF, Agra-Kooijman DM, Kumar S, Byrn SR, Shalaev EY. [http://www.ncbi.nlm.nih.gov/pubmed/21721005 Crystalline, liquid crystalline, and isotropic phases of sodium deoxycholate in water.] ''J Pharm Sci'' 2011 Nov;100(11):4836-44. doi: 10.1002/jps.22690. Epub 2011 Jun 30.</li>


Emeje, Martins; Olaleye, Olajide; Isimi, Christiana; Fortunak, Joseph; Byrn, Stephen; Kunle, Olobayo; Ofoefule, Sabinus. Oral sustained release tablets of zidovudine using binary blends of natural and synthetic polymers. ''Biological & Pharmaceutical Bulletin'' 2010;33(9):1561-157.  
<li>Byrn SR, Tishmack PA, Milton MJ, van de Velde H.  [http://www.ncbi.nlm.nih.gov/pubmed/21455817 Analysis of two commercially available bortezomib products: differences in assay of active agent and impurity profile.] AA''PS PharmSciTech'' 2011 Jun;12(2):461-7. Epub 2011 Apr 1.</li>


Ripin, David H. Brown; Teager, David S.; Fortunak, Joseph; Basha, Shaik Mahaboob; Bivins, Nylea; Boddy, Christopher N.; Byrn, Stephen; Catlin, Kelly K.; Houghton, Stephen R.; Jagadeesh, S. Tirumala; et al. Process Improvements for the Manufacture of Tenofovir Disoproxil Fumarate at Commercial Scale. ''Organic Process Research & Development'' 2010;14(5):1194-1201.
<li>Lee, Eun Hee; Boerrigter, Stephan X. M.; Byrn, Stephen R. [http://pubs.acs.org/doi/abs/10.1021/cg900549h Epitaxy of a Structurally Related Compound on the (100) Faces of Flufenamic Acid Form I and III Single Crystals.] ''Crystal Growth & Design'' 2010;10(2):518–527. doi: 10.1021/cg900549h. Epub January 8, 2010.</li>


Lee, Eun Hee; Byrn, Stephen R. Stabilization of metastable flufenamic acid by inclusion of mefenamic acid: solid solution or epilayer? ''J Pharm Sci'' 2010;99(9):4013-4022.  
<li>Ito, Takanori; Byrn, Stephen; Chen, Xin; Carvajal, M. Teresa. [http://www.ncbi.nlm.nih.gov/pubmed?term=Thermal%20insight%20of%20mechanically%20activated%20bile%20acid%20powders%2C Thermal insight of mechanically activated bile acid powders.] ''Int J Pharm.'' 2011 Nov 25;420(1), 68-75.</li>


Engers, David; Teng, Jing; Jimenez-Novoa, Jonathan; Gent, Philip; Hossack, Stuart; Campbell, Cheryl; Thomson, John; Ivanisevic, Igor; Templeton, Alison; Byrn, Stephen; et al. A solid-state approach to enable early development compounds: selection and animal bioavailability studies of an itraconazole amorphous solid dispersion. ''J Pharm Sci'' 2010;99(9):3901-3922.  
<li>Emeje, Martins; Isimi, Christiana; Byrn, Stephen; Fortunak, Joseph; Kunle, Olobayo; Ofoefule, Sabinus. [http://ijpr.sbmu.ac.ir/?_action=articleInfo&article=971 Extraction and physicochemical characterization of a new polysaccharide obtained from the fresh fruits of Abelmoschus esculentus.] ''Iranian Journal of Pharmaceutical Research'' 2011; 10(2):237-246.</li>


</div>
<li>Byrn, Stephen R.; Tishmack, Patrick A.; Milton, Mark J.; Velde, Helgi. [http://www.ncbi.nlm.nih.gov/pubmed?term=Analysis%20of%20Two%20Commercially%20Available%20Bortezomib%20Products%3A%20Differences%20in%20Assay%20of%20Active%20Agent%20and%20Impurity%20Profile. Analysis of Two Commercially Available Bortezomib Products: Differences in Assay of Active Agent and Impurity Profile.] ''AAPS PharmSciTech'' 2011 Jun;12(2):461-7. Epub 2011 Apr 1.</li>


<div style="width: 750px">
<li>Yamauchi, Masahiro; Lee, Eun Hee; Otte, Andrew; Byrn, Stephen R.; Carvajal, M. Teresa. [http://www.pubs.acs.org/doi/abs/10.1021/cg101098v?prevSearch=Contrasting%2Bthe%2BSurface%2Band%2BBulk%2BProperties%2Bof%2BAnhydrate%2Band%2BDehydrated%2BHydrate%2BMaterials&searchHistoryKey= Contrasting the Surface and Bulk Properties of Anhydrate and Dehydrated Hydrate Materials.] ''Crystal Growth & Design'' 2011;11(3):692-698.</li>
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<li>Trasi, Niraj S.; Boerrigter, Stephan X. M.; Byrn, Stephen R.; Carvajal, Teresa M. [http://www.sciencedirect.com/science/article/pii/S0378517311000160 Investigating the effect of dehydration conditions on the compactibility of glucose.] ''Int J Pharm'' 2011;406(1-2):55-61.</li>
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<li>Mao, Chen; Prasanth Chamarthy, Sai; Byrn, Stephen R.; Pinal, Rodolfo. [http://www.ncbi.nlm.nih.gov/pubmed?term=Theoretical%20and%20Experimental%20Considerations%20on%20the%20Enthalpic%20Relaxation%20of%20Organic%20Glasses%20using%20Differential%20Scanning%20Calorimetry. Theoretical and Experimental Considerations on the Enthalpic Relaxation of Organic Glasses using Differential Scanning Calorimetry.] ''Journal of Physical Chemistry B'' 2010;114(1):269-279.</li>
</div>
 
<li>Emeje, Martins; Olaleye, Olajide; Isimi, Christiana; Fortunak, Joseph; Byrn, Stephen; Kunle, Olobayo; Ofoefule, Sabinus. [http://www.ncbi.nlm.nih.gov/pubmed/20823575 Oral sustained release tablets of zidovudine using binary blends of natural and synthetic polymers.] ''Biological & Pharmaceutical Bulletin'' 2010;33(9):1561-157.</li>
 
<li>Ripin, David H. Brown; Teager, David S.; Fortunak, Joseph; Basha, Shaik Mahaboob; Bivins, Nylea; Boddy, Christopher N.; Byrn, Stephen; Catlin, Kelly K.; Houghton, Stephen R.; Jagadeesh, S. Tirumala; et al. [http://www.mendeley.com/research/process-improvements-manufacture-tenofovir-disoproxil-fumarate-commercial-scale-abstract/ Process Improvements for the Manufacture of Tenofovir Disoproxil Fumarate at Commercial Scale.] ''Organic Process Research & Development'' 2010;14(5):1194-1201.</li>
 
<li>Lee, Eun Hee; Byrn, Stephen R. [http://onlinelibrary.wiley.com/doi/10.1002/jps.22250/abstract Stabilization of metastable flufenamic acid by inclusion of mefenamic acid: solid solution or epilayer?] ''J Pharm Sci'' 2010;99(9):4013-4022.</li>
 
<li>Engers, David; Teng, Jing; Jimenez-Novoa, Jonathan; Gent, Philip; Hossack, Stuart; Campbell, Cheryl; Thomson, John; Ivanisevic, Igor; Templeton, Alison; Byrn, Stephen; et al. [http://onlinelibrary.wiley.com/doi/10.1002/jps.22233/abstract A solid-state approach to enable early development compounds: selection and animal bioavailability studies of an itraconazole amorphous solid dispersion.] ''J Pharm Sci'' 2010;99(9):3901-3922.</ol></div>
 
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Revision as of 07:08, 22 July 2014

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Recent Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=byrn%2C+stephen+r

  1. Fortunak, J.; Byrn, S.R.; Dyson, B.; Ekeocha, Z.; Ellison, T.; King, C.L.; Kulkarni, A.A.; Lee, M.; Conrad, C.; Thompson, K., An efficient, green chemical synthesis of the malaria drug, piperaquine, Tropical Journal of Pharmaceutical Research (2013), 12(5), 791-798.
  2. Lee, J.; Boerrigter, S.X.M.; Jung, Y.W.; Byun, Y.; Yuk, S.H.; Byrn, S.R.; Lee, E.H, Organic vapor sorption method of isostructural solvates and polymorph of tenofovir disoproxil fumarate, European Journal of Pharmaceutical Sciences (2013), 50(3-4), 253-262.
  3. Weber, J.K.R.; Benmore, C.J.; Tailor, A.N.; Tumber, S.K.; Neuefeind, J.; Cherry, B.; Yarger, J.L.; Mou, Q.; Weber, W.; Byrn, S.R. A neutron-X-ray, NMR and calorimetric study of glassy Probucol synthesized using containerless techniques, Chemical Physics (2013), 424, 89-92.
  4. Benmore, C.J.; Weber, J.K.R.; Tailor, A.N.; Cherry, B.R.; Yarger, J.L.; Mou, Q.; Weber, W.; Neuefeind, J.; Byrn, S.R., Structural characterization and aging of glassy pharmaceuticals made using acoustic levitation, Journal of Pharmaceutical Sciences (2013), 102(4), 1290-1300.
  5. Gurvich, V.J; Byrn, S.R., NIPTE: a multi-university partnership supporting academic drug development, Drug Discovery Today (2013), 18(19-20), 916-21.
  6. Byrn, Stephen R, and Henck, Jan-Olav. Optimizing Physical Form – opportunities and limitations. Drug Discovery Today: Technologies 2012; 9(2): e73-e78.
  7. Lee EH, Byrn SR, Pinal R. The solution properties of mefenamic acid and a closely related analogue are indistinguishable in polar solvents but significantly different in nonpolar environments. J Pharm Sci 2012 Dec;101(12):4529-39. doi: 10.1002/jps.23316. Epub 2012 Sep 12.
  8. Trasi NS, Byrn SR. Mechanically induced amorphization of drugs: a study of the thermal behavior of cryomilled compounds. AAPS PharmSciTech 2012 Sep;13(3):772-84. doi: 10.1208/s12249-012-9801-8. Epub 2012 May 15. [PubMed - in process]
  9. Weber RJ, Benmore CJ, Tumber SK, Tailor AN, Rey CA, Taylor LS, Byrn SR. Acoustic levitation: recent developments and emerging opportunities in biomaterials research. Eur Biophys J 2012 Apr;41(4):397-403. doi: 10.1007/s00249-011-0767-3. Epub 2011 Oct 30.
  10. Su Z, Luthra S, Krzyzaniak JF, Agra-Kooijman DM, Kumar S, Byrn SR, Shalaev EY. Crystalline, liquid crystalline, and isotropic phases of sodium deoxycholate in water. J Pharm Sci 2011 Nov;100(11):4836-44. doi: 10.1002/jps.22690. Epub 2011 Jun 30.
  11. Byrn SR, Tishmack PA, Milton MJ, van de Velde H. Analysis of two commercially available bortezomib products: differences in assay of active agent and impurity profile. AAPS PharmSciTech 2011 Jun;12(2):461-7. Epub 2011 Apr 1.
  12. Lee, Eun Hee; Boerrigter, Stephan X. M.; Byrn, Stephen R. Epitaxy of a Structurally Related Compound on the (100) Faces of Flufenamic Acid Form I and III Single Crystals. Crystal Growth & Design 2010;10(2):518–527. doi: 10.1021/cg900549h. Epub January 8, 2010.
  13. Ito, Takanori; Byrn, Stephen; Chen, Xin; Carvajal, M. Teresa. Thermal insight of mechanically activated bile acid powders. Int J Pharm. 2011 Nov 25;420(1), 68-75.
  14. Emeje, Martins; Isimi, Christiana; Byrn, Stephen; Fortunak, Joseph; Kunle, Olobayo; Ofoefule, Sabinus. Extraction and physicochemical characterization of a new polysaccharide obtained from the fresh fruits of Abelmoschus esculentus. Iranian Journal of Pharmaceutical Research 2011; 10(2):237-246.
  15. Byrn, Stephen R.; Tishmack, Patrick A.; Milton, Mark J.; Velde, Helgi. Analysis of Two Commercially Available Bortezomib Products: Differences in Assay of Active Agent and Impurity Profile. AAPS PharmSciTech 2011 Jun;12(2):461-7. Epub 2011 Apr 1.
  16. Yamauchi, Masahiro; Lee, Eun Hee; Otte, Andrew; Byrn, Stephen R.; Carvajal, M. Teresa. Contrasting the Surface and Bulk Properties of Anhydrate and Dehydrated Hydrate Materials. Crystal Growth & Design 2011;11(3):692-698.
  17. Trasi, Niraj S.; Boerrigter, Stephan X. M.; Byrn, Stephen R.; Carvajal, Teresa M. Investigating the effect of dehydration conditions on the compactibility of glucose. Int J Pharm 2011;406(1-2):55-61.
  18. Mao, Chen; Prasanth Chamarthy, Sai; Byrn, Stephen R.; Pinal, Rodolfo. Theoretical and Experimental Considerations on the Enthalpic Relaxation of Organic Glasses using Differential Scanning Calorimetry. Journal of Physical Chemistry B 2010;114(1):269-279.
  19. Emeje, Martins; Olaleye, Olajide; Isimi, Christiana; Fortunak, Joseph; Byrn, Stephen; Kunle, Olobayo; Ofoefule, Sabinus. Oral sustained release tablets of zidovudine using binary blends of natural and synthetic polymers. Biological & Pharmaceutical Bulletin 2010;33(9):1561-157.
  20. Ripin, David H. Brown; Teager, David S.; Fortunak, Joseph; Basha, Shaik Mahaboob; Bivins, Nylea; Boddy, Christopher N.; Byrn, Stephen; Catlin, Kelly K.; Houghton, Stephen R.; Jagadeesh, S. Tirumala; et al. Process Improvements for the Manufacture of Tenofovir Disoproxil Fumarate at Commercial Scale. Organic Process Research & Development 2010;14(5):1194-1201.
  21. Lee, Eun Hee; Byrn, Stephen R. Stabilization of metastable flufenamic acid by inclusion of mefenamic acid: solid solution or epilayer? J Pharm Sci 2010;99(9):4013-4022.
  22. Engers, David; Teng, Jing; Jimenez-Novoa, Jonathan; Gent, Philip; Hossack, Stuart; Campbell, Cheryl; Thomson, John; Ivanisevic, Igor; Templeton, Alison; Byrn, Stephen; et al. A solid-state approach to enable early development compounds: selection and animal bioavailability studies of an itraconazole amorphous solid dispersion. J Pharm Sci 2010;99(9):3901-3922.

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