Biomod/2014/VCCRI/Project

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<div class="navbar navbar-default navbar-fixed-top" role="navigation" style="font-family: arial bold; font-size: 125%; box-shadow: 0px 0px 10px 10px rgba(0,0,0,0.4);"> <div class="container"> <div class="navbar-collapse collapse"> <ul class="nav navbar-nav"> <li><a href="http://openwetware.org/wiki/Biomod/2014/VCCRI">Home</a></li> <li class="active"><a href="http://openwetware.org/wiki/Biomod/2014/VCCRI/Project">Project</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2014/VCCRI/Team">Team</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2014/VCCRI/LabBook">Lab Book</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2014/VCCRI/Sponsors">Sponsors</a></li> </ul> </div><!--/.nav-collapse --> </div> </div>

<div class="container" style="text-align:center; margin-top: 100px;"> <div class="row row-centered"> <div class="col-xs-8 col-centered col-min"><div class="item"><div class="content"> <div id="PROJECT-UNDER-CONSTRUCTION"></div> <div id="PROJECT-ABSTRACT-BACKGROUND"> <div id="PROJECT-CONSTRUCTION-TEXT"> <p class="text-justify"><img src="http://openwetware.org/images/f/ff/2014-EchiDNA-PROJECT-ABSTRACT-IMAGE-1.png" align="right" style="padding-left:10px; padding-bottom: 10px;"/>What is the difference between a few undergraduates and a BIOMOD team? Or between a single ant and a colony of social insects? What about a population of individual cells and a multicellular organism? Between monodispersed proteins and a multi-protein complex like the bacterial flagella motor? What is the difference between a set of oligos and a DNA nanomachine?</p>

<p class="text-justify">It is believed that cooperativity between staples expedites the assembly of folding DNA origami <span style="color:#f7941e; font-weight: bold;">structures</span>. We aim to design, build and characterise a DNA nanomachine that exhibits cooperativity in its <span style="color:#f7941e; font-weight: bold;">function</span>. We have drawn inspiration primarily from two sources in the design of our DNA biosensor - the molecular beacons used routinely to identify trace amounts of DNA and the switching mechanism of the bacterial flagella motor. Here we construct a circular ring of DNA switches which are tethered together such that they essentially 'vote' whether to undergo a conformational change. This project has the potential to inform realistic models of the molecular mechanics of bionanomachines, but also to provide a cheap, robust alternative to existing DNA biosensors. Our design is modular, so that the DNA targeted by our biosensor might be anything - an HIV virus, a mutation associated with cancer, a gene causing antibiotic resistance. Furthermore, our biosensor is accompanied by an extensive mathematical model of its dynamics and thus we hope it will be tuneable to specific outputs.</p> </div> </div>


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       <p style="font-family: arial; text-align: center; font-size: 85%; font-family: FOOTER_font, Arial, serif;">Contact: <a href="mailto:BIOMODaustralia@gmail.com">BIOMODaustralia@gmail.com</a> | &copy;2014 Team EchiDNA. All rights reserved. This team is supported by the <a id="vccri" href="http://www.victorchang.edu.au">Victor Chang Cardiac Research Institute</a>. | <a id="vccri" href="http://openwetware.org/index.php?title=Biomod/2014/VCCRI/Project&action=edit">Edit</a></p>
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Contact: <a href="mailto:BIOMODaustralia@gmail.com">BIOMODaustralia@gmail.com</a> | ©2014 Team EchiDNA. All rights reserved. This team is supported by the <a id="vccri" href="http://www.victorchang.edu.au">Victor Chang Cardiac Research Institute</a>. | <a id="edit-link" href="">Edit</a>

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