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| {{Komaba2014}}
| | [http://biomod2014komaba.github.io/ University of Tokyo, Komaba — UT-Komaba] |
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| <html>
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| <body>
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| <style>
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| #project{
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| margin-left: auto ;
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| margin-right: auto ;
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| width:800px;
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| }
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| </style>
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| <div id="project">
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| <h2>Problems</h2>
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| <p>Today, there are some methods for making nanoscale 2-dimentional structure, but it is still difficult to make 3-dimentional structure accurately,particularly in nanoscale.
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| If we can make 3-dimentional structure in nanoscale optionally,it must be useful in many fields. For example, regular nanoscale structure is so useful for many things such as researching chemical reaction and new materials.
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| And if that nanoscale structure is able to formed in our body, for example in capillary,this method can be help so many people who is suffered from high blood pressure. Or it may be able to use smart DDS and so on. </p>
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| <h2>The outline of the solution</h2>
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| <p>The goal of this project is to create “DNA mag-beads.” “DNA mag-beads” are made from magnetic beads and 2 kinds of DNA with Carboxyvinyl Uracil (cvU) on both hemisphere of bead. This 2kinds of DNA have mutual complementarity. These DNA combine with complementary strand on next bead and beads are lined up. When light is irradiated, cvU join together. Bonds between beads become enough strong to use for nanotechnology and medical technology. These strings made from “DNA mag-beads” are basic units. We can bind these strings together and make sheets and 3-dimentional structures in high precision, because “DNA mag-beads” is at nanoscale.
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| Magnetic beads can be localized at specific area by applying a magnetic field to them. So we can raise efficiency of making DNA mag-beads and adjust density of 3-dimentional structure to apply a magnetic field from outside of a container.
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| And magnetic beads generate heat by applying high-frequency waves and bead itself has a high temperature. So any point of DNA between beads can be cut.
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| Both magnetic field and high-frequency wave can operate by remote control. That is, we may be able to make optional 3-dimentional structure in high precision at optional point.
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| </p>
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| </div>
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| </body>
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| </html>
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Latest revision as of 08:30, 26 October 2014