Biomod/2014/Kashiwa/Project: Difference between revisions

Revision as of 03:02, 30 September 2014

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 <ul id="menu">
 <font face="Frutiger,Helvetica,Arial">
   <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa"><img src="http://openwetware.org/images/e/ec/LogoKashiwa.png" onmouseover="this.src='http://openwetware.org/images/7/7a/Logo2Kashiwa.png'" onclick="this.src='http://openwetware.org/images/1/1d/Logo2.5.png'" onmouseout="this.src='http://openwetware.org/images/e/ec/LogoKashiwa.png'" height="80px" width="120px" name="def"></a>
   </li>
   <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Project" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">PROJECT</span></a>
     <ul class="sub">
       <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Project#1" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">Background</span></a></li>
       <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Project#2" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">Motivation</span></a></li>
       <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Project#3" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">Project Goals</span></a></li>
     </ul>
   </li>
   <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Trial" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">&nbsp;EARLY TRIAL&nbsp;</span></a>
     <ul class="sub">
       <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Trial#1" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">Design</span></a></li>
       <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Trial#2" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">Approaches</span></a></li>
     </ul>
   </li>
   <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Design" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">DESIGN</span></a>
     <ul class="sub">
       <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Design#2" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">The Receptor</span></a></li>
       <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Design#1" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">The Motor</span></a></li>
     </ul>
   </li>
   <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Highlights" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">&nbsp;EXPERIMENT&nbsp;&nbsp;</span></a>
     <ul class="sub">
       <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Highlights" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">Highlights</span></a></li>
       <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Receptor" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">The Receptor</span></a></li>
       <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Motor" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">The Motor</span></a></li>
     </ul>
   <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Discussion" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">&nbsp;&nbsp;DISCUSSION&nbsp;</span></a>
     <ul class="sub">
       <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Discussion#1" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">Achievements</span></a></li>
       <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Discussion#2" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">Future</span></a></li>
     </ul>
   </li>
   <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Protocols" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">PROTOCOL</span></a>
   </li>
   <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Team" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">TEAM</span></a>
     <ul class="sub">
       <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Team#1" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">Members</span></a></li>
       <li><a href="http://openwetware.org/wiki/Biomod/2014/Kashiwa/Team#2" onMouseOver="On('img1')" onMouseOut="Off()"><span style="font-size:12pt;">Sponsors</span></a></li>
     </ul>
   </li>
 </font>
 </ul>

</div> <br> <br> <br> <div class="page-back"><a href="#top"> <img src="http://openwetware.org/images/2/2a/Top1.gif" onmouseover="this.src='http://openwetware.org/images/f/f0/Top2.gif'" onmouseout="this.src='http://openwetware.org/images/2/2a/Top1.gif'" height="150px"/></a></div> </head>

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<body> <a name="1"></a> <font face="Futura,Arial,Frutiger" font size="24px">PROJECT</font> <br> <br> <h1 class="title"><a name="background"> Background</a></h1> <font style="font-size:32px;">  <i>Limitation of DDS</i></font> <br> <p class="paragraph">Drug Delivery System (DDS) is a general term for the various ways to deliver drugs selectively to pathogens while avoiding normal cells, which has been widely researched by scientists. Most researches aim at creating ways to target or attack pathogens and few of them attend to a way to transfer drugs. In other words, in most DDS, the transfers rely only on diffusion, which limits the possibilities of DDS. For example, in cancer treatments, excessive drugs cause side effects while insufficient drugs cannot kill the cancer cells completely and remaining cancer cells will reproduce or metastasize. </p>

<br><br> <h1 class="title"><a name="background"> Motivation</a></h1> <font style="font-size:32px;">  <i>Creating a new way of transfer</i></font> <br> <p class="paragraph">We considered that if a new way to transfer drugs is created, the cancer cells are killed more efficiently with fewer drugs, leads to expand the possibilities of DDS. We decided to create a new way to transfer drugs; build a patrolling nano-robot which moves not only by diffusion but also by self-propulsion. The nano-robot can reach parts where ordinary DDS cannot, such as the depth of the tumors, which makes DDS more efficient. Moreover, nano-scale steps of the robot enable a single cell resolution in DDS.</p>

<br> <font style="font-size:32px;">  <i>Strategy of the self-moving robot</i></font> <br> <p class="paragraph">To make such a nano-robot, we drew inspiration from a dendritic immune cell which moves in a body by migration. The cell has spines that are small actin-rich protrusions; by remodeling (polymerizing and depolymerizing) actin filaments inside, it can change shape and migrate.</p> <p class="paragraph">Based on this idea, we developed actin-like monomers (named “Motor-Monomers”) and put them into a liposome which the “Receptor” is inserted as a starter switch. When the Receptor recognizes the outside signal, the Motor-Monomers start polymerization to become the Motor-Polymer. The Motor-Polymer should polymerize in one end and depolymerize in the other end to mimic actin filaments.</p> <p class="paragraph">As we modeled this polymerizing-in-a-liposome system on a dendritic immune cell, we named it "Polymeric and Liposomal Immune Cell (<b>PoLICe</b>)."</p>

<br><br> <h1 class="title"><a name="background"> Project Goals</a></h1> <p class="paragraph">Since we have to accomplish our project during the summer, we focused on one aspect of the PoLICe system, polymerization. Therefore, we aimed to achieve a deformation of a liposome which follows polymerization. To achieve this goal, we planned three main steps.</p> <p class="paragraph">First, we need to develop a sensing system which works as a start switch of the Motor, so that we can control when PoLICe starts patrolling. In order to achieve the system, we planned to design the following Receptor: It is embedded in a liposome and when recognizing the outside signal it activates the Motor-Monomers to become the Motor-Polymer.</p> <p class="paragraph">Second, we need to develop a moving system which works as the motor of the PoLICe. In order to achieve the system, we planned to design the following Motor-Monomers: They are put into the liposome at the inactivated state and start polymerization when the Receptor switches on.</p> <p class="paragraph">Finally, we need to connect two systems with each other and assay to verify the deformation of the liposome.</p> <br> <br> <br> <h2 class="reference">Reference</h2> <p class="reference">1.All Cancer (excluding non-melanoma skin cancer) Estimated Incidence, Mortality and Prevalence Worldwide in 2012 from International Agency for Research on Cancer website; http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx</p> </body>

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Biomod/2014/Kashiwa/Project: Difference between revisions

Revision as of 03:02, 30 September 2014

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@@ Line 23: / Line 23: @@
 <font style="font-size:32px;">&nbsp;&nbsp;<i>Creating a new way of transfer</i></font>
 <br>
-<p class="paragraph">We considered that if a new way to transfer drugs is created, the cancer cells are killed more efficiently with fewer drugs, should expand the possibilities of DDS. We decided to create a new way to transfer drugs.</p>
+<p class="paragraph">We considered that if a new way to transfer drugs is created, the cancer cells are killed more efficiently with fewer drugs, leads to expand the possibilities of DDS. We decided to create a new way to transfer drugs; build a patrolling nano-robot which moves not only by diffusion but also by self-propulsion. The nano-robot can reach parts where ordinary DDS cannot, such as the depth of the tumors, which makes DDS more efficient. Moreover, nano-scale steps of the robot enable a single cell resolution in DDS.</p>
-<p class="paragraph">Our goal is to build a patrolling nano-robot which moves not only by diffusion but also by self-propulsion. The nano-robot can reach parts where ordinary DDS cannot, such as the depth of the tumors, which makes DDS more efficient. Moreover, nano-scale steps of the robot enable a single cell resolution in DDS.</p>
 <br>