Biomod/2013/Todai: Difference between revisions

Latest revision as of 17:45, 26 October 2013

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<body>

   <div id="top">	
     <figure>
       <div  class="Logo">
         <img src="http://openwetware.org/images/9/9c/Logo-OCKver.png" width=730px height=128px>
       </div>
     </figure>
   </div>
   <br>

 <ul>
    <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai">Home</a>
    </li>
    <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Project">Project</a>
    </li>
    <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Design">Design</a>
    </li>
    <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Result">Result</a>
    </li>
    <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Experiment">Experiment</a>
       <ul style="list-style-type: none;">

<li>

          <a href="http://openwetware.org/wiki/Biomod/2013/Todai/Experiment#Contents">
          Contents</a></li>
          <li>
          <a href="http://openwetware.org/wiki/Biomod/2013/Todai/Experiment#PilotStudy">
          Pilot Study</a></li>
          <li>
          <a href="http://openwetware.org/wiki/Biomod/2013/Todai/Experiment#Protocols">
          Protocols</a></li>
       </ul>
    </li>
    <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Team">Team</a>
    </li>
    <li><a href="http://openwetware.org/wiki/Biomod/2013/Todai/Sponsors">Sponsors</a>
    </li>
 </ul>

</div>

 <a href="#TOP">
   <figure>
     <img src="http://openwetware.org/images/b/b1/Return-top-0828new.png" width:60px height:60px>
   </figure>
 </a>

</div>

</body> </html>

<html> <head> <style> .to-project a{

 font-size:130%;
 position:relative;
 left:500px;
 }

</style> </head>

<body>

  <h1 class="big-title"><a name="Home">&nbsp;Home</a></h1>
  <br>

  <article>
   <h1 class="title"><a name="Oligomeric Cell Killer">&nbsp;Oligomeric Cell

Killer</a></h1>

    <p class="paragraph">Team Todai nanORFEVRE tried to make cancer-specific

pore-forming DNA origami drug.</p>

   <p class="paragraph">We named this DNA nanostructure "Oligomeric Cell

Killer".</p>

  </article>

  <br>
  <article>
     <h1 class="title"><a name="Abstract">&nbsp;Abstract</a></h1>
     <br>
  <center><iframe width="480" height="360" src="//www.youtube.com/embed/E4RaZ41hJ7w" frameborder="0" allowfullscreen></iframe>
  </center>

<br>

  <center>
  <figure>
  <img src="http://openwetware.org/images/4/46/Todai_home.png" width="450px"

height="350px" >

  </center>
  </figure>
  <br>

  <p class="paragraph">

Cancer is one of the most common diseases in the world. Chemotherapy is a

popular treatment for cancer, however, it attacks normal cells in addition to

cancer cells, causing severe side effects in some cases. Recently drug

delivery system (DDS) has developed to improve cancer-specificity, but it is

difficult to optimize delivery system for each drug.

  </p>
   <br>
 <p class="paragraph">

Here, we tried to make a prototype of <span style="color:#e00000">oligomeric

cancer specific pore-forming DNA origami</span>, termed <span

style="color:#e00000"><b>Oligomeric Cell Killer (OCK)</b></span>, which might

be a side effects free anti-cancer drug.

  </p>
  <br>
 <p class="paragraph">

OCKs exist in a monomeric form in solution and penetrate into the cell

randomly. Cancer specific molecules on the membrane of cancer cell trigger

the oligomerization of OCK, resulting in the pore-forming and <span

style="color:#e00000">subsequent death of cancer cell</span>. In contrast,

the OCKs keep monomeric form in the normal cell, allowing <span

style="color:#e00000">the normal cell to keep alive</span>.

Our study might be the basis for cancer specific drug. 
  </p>
  <br>

    <div class="to-project">
    <a href="http://openwetware.org/wiki/Biomod/2013/Todai/Project">
    ＞＞To Project＜＜

    </a>
    </div>

  </article>
  <br>
  <br>
  <br>
  <br>
  <br>
  <br>
  <br>
  <br>

Biomod/2013/Todai: Difference between revisions

Latest revision as of 17:45, 26 October 2013

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@@ Line 20: / Line 20: @@
     <article>
-     <h1 class="title"><a name="Oligomeric Cell Killer">&nbsp;Oligomeric Cell Killer</a></h1>
+     <h1 class="title"><a name="Oligomeric Cell Killer">&nbsp;Oligomeric Cell
-      <p class="paragraph">Team Todai nanORFEVRE tried to make cancer-specific pore-forming DNA origami drug.</p>
-     <p class="paragraph">We named this DNA nanostructure "Oligomeric Cell Killer".</p>
+Killer</a></h1>
+      <p class="paragraph">Team Todai nanORFEVRE tried to make cancer-specific
+pore-forming DNA origami drug.</p>
+     <p class="paragraph">We named this DNA nanostructure "Oligomeric Cell
+Killer".</p>
     </article>
@@ Line 29: / Line 35: @@
        <h1 class="title"><a name="Abstract">&nbsp;Abstract</a></h1>
        <br>
+   <center><iframe width="480" height="360" src="//www.youtube.com/embed/E4RaZ41hJ7w" frameborder="0" allowfullscreen></iframe>
+   </center>
+<br>
     <center>
     <figure>
-    <img src="http://openwetware.org/images/4/46/Todai_home.png" width="450px" height="350px" >
+    <img src="http://openwetware.org/images/4/46/Todai_home.png" width="450px"
+height="350px" >
     </center>
     </figure>
@@ Line 37: / Line 48: @@
     <p class="paragraph">
-Cancer is one of the most common diseases in the world. Chemotherapy is a popular treatment for cancer, however, it attacks normal cells in addition to cancer cells, causing severe side effects in some cases. Recently drug delivery system (DDS) has developed to improve cancer-specificity, but it is difficult to optimize delivery system for each drug.
+Cancer is one of the most common diseases in the world. Chemotherapy is a
+popular treatment for cancer, however, it attacks normal cells in addition to
+cancer cells, causing severe side effects in some cases. Recently drug
+delivery system (DDS) has developed to improve cancer-specificity, but it is
+difficult to optimize delivery system for each drug.
     </p>
      <br>
    <p class="paragraph">
-Here, we tried to make a prototype of <span style="color:#e00000">oligomeric cancer specific pore-forming DNA origami</span>, termed  <span style="color:#e00000"><b>Oligomeric Cell Killer (OCK)</b></span>, which might be a side effects free anti-cancer drug.
+Here, we tried to make a prototype of <span style="color:#e00000">oligomeric
+cancer specific pore-forming DNA origami</span>, termed  <span
+style="color:#e00000"><b>Oligomeric Cell Killer (OCK)</b></span>, which might
+be a side effects free anti-cancer drug.
     </p>
     <br>
    <p class="paragraph">
-OCKs exist in a monomeric form in solution and penetrate into the cell randomly. Cancer specific molecules on the membrane of cancer cell trigger the oligomerization of OCK, resulting in the pore-forming and <span style="color:#e00000">subsequent death of cancer cell</span>. In contrast, the OCKs keep monomeric form in the normal cell, allowing <span style="color:#e00000">the normal cell to keep alive</span>.
+OCKs exist in a monomeric form in solution and penetrate into the cell
+randomly. Cancer specific molecules on the membrane of cancer cell trigger
+the oligomerization of OCK, resulting in the pore-forming and <span
+style="color:#e00000">subsequent death of cancer cell</span>. In contrast,
+the OCKs keep monomeric form in the normal cell, allowing <span
+style="color:#e00000">the normal cell to keep alive</span>.
   Our study might be the basis for cancer specific drug.
     </p>