Biomod/2013/StJohns/approaches

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Claw

(placeholder for explanation of Matt's project)

Selection

(Placeholder for explanation of Keshia's project)

Antibodies

In this approach, the goal is to generate small anti-Flag Fab fragments for potential use as binding elements in future claw designs (visualized as small red protrusions on our models of the claw). These anti-Flag Fab fragments are generated from a larger antibody protein molecule called Immunoglobulin G (IgG).


As can be seen in the figure below, the IgG can be cleaved by an enzyme called ficin. The result yields two Fab fragments per IgG molecule. The sample gel on the right displays the relative mobilities and quantities of these fragments and IgG. Notice that the IgG shows up at around 150 kDa and Fab fragments show up at around 50 kDa.

File:Lukemanlab-2013-0008.png

Triangles

(Placeholder for explanation of Mike's project)

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