DNA-based nanotechnology utilizes the exquisite selectivity of the Watson-Crick base-pair, combined with deep understanding and control of double-helical structure gleaned from physics, molecular biology, chemistry and nanotechnology, to program the self-assembly of nanometer-scale objects.
The goal of this project is the creation of a DNA origami structure that undergoes significant conformational changes when bound to objects ranging in size from 10-100 nm. Since binding-specific conformational change can be transduced into a signal, this should enable the design of robust sensors for a wide variety of nano-scale objects, such as viruses.
We especially wish to acknowledge
- Matthew Francis, for providing the functionalized MS2 capsids used for these experiments
- Matthew Francis and Hao Yan, whose paper  inspired the use of these sticky capsids with origami as a model system for virus binding
- Masayuki Endo, whose design  provided the basis for this one