Biomod/2013/StJohns: Difference between revisions

From OpenWetWare
Jump to navigationJump to search
No edit summary
No edit summary
 
(28 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Template:Biomod/2013/StJohns}}
{{Template:Biomod/2013/StJohns}}


(this page should have <45seconds of content and fit on single screen with no scrolling, this is a visual elevator pitch)
<br>
DNA-based nanotechnology utilizes the exquisite selectivity of the Watson-Crick base-pair, combined with deep understanding and control of double-helical structure gleaned from physics, molecular biology, chemistry and nanotechnology, to program the self-assembly of nanometer-scale objects.


[[Image:Lukemanlab-2013-afm-1.tif|border|center|450px|link=Biomod/2013/StJohns/Concept]]
[[Biomod/2013/StJohns/introduction|<html><center><img src="http://openwetware.org/images/thumb/a/aa/Lukemanlab-Claw%2Bcapsid_cartoon.png/800px-Lukemanlab-Claw%2Bcapsid_cartoon.png"></center></html>]]


(above image is placeholder for 'concept' cartoon or splash image, NOT ANIMATED, linked to intro or concept page)


Ph'nglui mglw'nafh Cthulhu R'lyeh wgah'nagl fhtagn. Nog nafm'latgh zhro hupadgh kn'a, ron nahrii fm'latgh Dagon hrii ah nog naflgoka Tsathoggua, y'hah nogog lw'nafh ebunma stell'bsna 'bthnk ngvulgtlagln ep lloig. Naya Chaugnar Faugn r'luh naflAzathoth ah sll'ha ebunma zhro gotha sll'ha ph'phlegeth shtunggli, Cthulhu ron ph'chtenff ph'uln ep Azathoth sgn'wahl sll'ha fm'latgh tharanak, Shub-Niggurath f'kadishtu geb kadishtu kn'a syha'h chtenff phlegeth Tsathoggua cah.
[[Biomod/2013/StJohns/introduction|The goal of this project]] is the creation of [[Biomod/2013/StJohns/design|a DNA origami structure]] that undergoes significant conformational changes when bound to objects ranging in size from 10-100 nm.  
Since binding-specific conformational change can be transduced into a signal, this should enable the design of robust sensors for a wide variety of nano-scale objects, such as viruses.
<br><br>
'''We especially wish to acknowledge'''
* Matthew Francis, for providing the [[Biomod/2013/StJohns/concept|functionalized MS2 capsids]] used for these experiments
* Matthew Francis and Hao Yan, [[Biomod/2013/StJohns/References|whose paper [3]]] inspired the use of these sticky capsids with origami  as a model system for virus binding
* Masayuki Endo, [[Biomod/2013/StJohns/References|whose design [2]]] provided the basis for [[Biomod/2013/StJohns/design|this one]]


Ah ya cuaaah ehye h'chtenff, kadishtu 'bthnk vulgtm wgah'n, ron shuggoth shogg.
 
 
 
 
 
<html><div style="text-align: center; font-weight: bold;>">We are team Toehold Conga Nanny.</div></html>
[[Image:Toehold-Conga-Nanny-logo.jpg|frameless|300px|center]]

Latest revision as of 09:09, 13 November 2013

<html>

<head>

<link href='http://fonts.googleapis.com/css?family=Open+Sans' rel='stylesheet' type='text/css'>

</head>



<style>

body { 

 font-family: 'Trebuchet MS', 'Open Sans', sans-serif;
 overflow-y: auto;

}

.container { 

 background-color: #ffffff;
 margin-top:0px

} .OWWNBcpCurrentDateFilled { display: none; }

h5 { 

 font-family: 'Trebuchet MS', 'Open Sans', sans-serif;
 font-size: 11px;
 font-style: normal;
 text-align: center;
 margin:0px;
 padding:0px;

}

  1. column-content

{ 

 width: 0px; 
 float: left; 
 margin: 0 0 0 0;
 padding: 0;

} .firstHeading { 

 display:none;
 width:0px;

}

  1. column-one

{ 

 display:none; 
 width:0px;
 background-color: #ffffff;

}

  1. globalWrapper

{ 

 width: 1024px;
 background-color: #ffffff;
 margin-left: auto;
 margin-right: auto

}

  1. content

{ 

 margin: 0 0 0 0;
 align: center;
 padding: 12px 12px 12px 12px;
 width: 1000px;
 background-color: #ffffff; border: 0;

}

  1. bodyContent

{ 

 width: 974px;
 align: justify;
 background-color: #fffffff;

}

  1. column-content

{ 

 width: 1024px;
 background-color: #ffffff;

}

  1. footer

{ 

 position: absolute;
 bottom: 0;
 width: 1024px;

}

  1. menu

{ 

 position: fixed;
 float: left;
 width: 180px;
 padding: 10px;
 background-color: #FFFFFF;

}

  1. resolutionwarning

{ 

 display: none;
 text-align: center;

}

  1. pagecontent

{ 

 text-align: justify;
 float: right;
 width: 744px;
 margin-left: 300px;
 min-height: 400px

}

  1. toc { display: none; }

@media all { 

   body { background: #ffffff 0 0 no-repeat;}

}

/*Expanding list*/ ul { list-style: none; }

  1. exp li ul { display: none; }
  2. exp li:hover ul { display: block; }
  3. exp li a:active ul { display: block; }

a:link {color:#007788;} /*unvisited link*/ a:visited {color:#007788;} /* visited link */ a:hover {color:#00ccff;} /* mouse over link */ a:active {color:#00ccff;} /* selected link */

</style> </html>

For optimal viewing experience, please enlarge this window to at least 1024 pixels.


DNA-based nanotechnology utilizes the exquisite selectivity of the Watson-Crick base-pair, combined with deep understanding and control of double-helical structure gleaned from physics, molecular biology, chemistry and nanotechnology, to program the self-assembly of nanometer-scale objects.

<html><center><img src="http://openwetware.org/images/thumb/a/aa/Lukemanlab-Claw%2Bcapsid_cartoon.png/800px-Lukemanlab-Claw%2Bcapsid_cartoon.png"></center></html>


The goal of this project is the creation of a DNA origami structure that undergoes significant conformational changes when bound to objects ranging in size from 10-100 nm. Since binding-specific conformational change can be transduced into a signal, this should enable the design of robust sensors for a wide variety of nano-scale objects, such as viruses.

We especially wish to acknowledge




<html><div style="text-align: center; font-weight: bold;>">We are team Toehold Conga Nanny.</div></html>

Retrieved from "https://openwetware.org/mediawiki/index.php?title=Biomod/2013/StJohns&oldid=756843"