BackgroundSensing and amplifying weak signals are critical for life things to adapt to the severe environment. These sensing and signal transduction systems have been highly developed to play the role in the course of evolution. For example, we can raise immune and neurotransmission systems. These systems work very effectively, however application usages of those are limited because they only work in living cells. Sensing and signal transduction systems made of purified biomolecules and/or chemicals will overcome the situation.
Motivation Signal transduction with defined biomolecules and chemicals needs two system; sensing systems to external signals and transmit systems to amplify the signals. Liposomes have high responsibility to environment and have been used to release molecules out from the inside. DNA is beneficial for specific-action and transmission, because of its high selective-specificity and flexibility. If above system is made of DNA and liposomes, we can realize the nano-scaled flexible amplifier. Thus, we aim at creating molecular-releasing systems using DNA and liposomes.