FutureThe advantage of our system is that large quantity of substances can be released in any limited place at any timing.
Our project will realize the following application.
Example 1 Sensing and curing inflammations in blood vesselsAs it is hard to recognize inflammations in blood vessels, they could get worse while you don’t know.
The only way to detect these inflammations has been undergoing physical checkups constantly. However, our project would enables us to detect these inflammations and gives us to enough time to cure them. In the case of inflammations in blood vessels, C-reactive protein (CRP) is released. Liposomes conjugated with phosphorylcholine (one of phosphatides; it reacts CRP) sense the inflammation area, breaks and release the key DNAs there.
Then, the released key DNAs hybridize and break other liposomes. By confining medicines in the liposomes, you can release them at narrow inflammation area effectively.
The application is not limited to inflammations. Our project would also offer effective treatment for cancer. As it can sense even unrecognizable trigger signal and releases large amount of drugs in a limited space, it would help us to detect cancer cells early and prevent side effects by anti-cancer agents.
Fig1.Sensing and curing inflammations in blood vessels
Example 2 molecular engineMoreover, focusing on the chain reaction, our system can be applied to long-lasting batteries for molecular engines. If some fuel for molecular engines (such as ATP) is packed inside the liposome, and the liposome is combined with some molecular motors (such as motor proteins), the fuel can be constantly supplied to the molecular motor by only one time initiation of the reaction.
The molecular motor would lead to molecular engines, and in the end, sophisticated molecular robots. Our system would make it possible to achieve molecular robots moving without continuous fuel supply from the outside.