ABSTRUCTWe are aiming at constructing a chain-reactive molecule-releasing system in this project.
In living organisms, signal transduction is widely used in many situations.
Here we construct a signal transduction-like system through an approach of DNA nano-engineering.
In our project, trigger DNAs and payload molecules are encapsulated in a liposome. The trigger DNA is specially designed to collapse the liposome when some initiation stimulus is applied. Once one of the liposomes collapsed, the trigger DNAs are released from the liposome and that break other liposomes in chain-reactive fashion. This mechanism of “chain-reactive burst” enables us to release a large amount of payload molecules all at once, driven by a faint trigger signal.
We believe this system offers a fundamental technique of signal transduction/amplification of various kinds of chemical or physical signals, applicable to Drug Delivery System, molecular computers and so on.