Biomod/2013/Sendai

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</style> </head> </html> <html xmlns="http://www.w3.org/1999/xhtml"> <head>

   <title>Biomod2013 Sendai ver2.0</title>
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<body><!-- <div style="max-width:900px; position:fixed;">****/ -->

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               <a href="#"  class="whiteSendai">Blog</a> 
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           <a href="http://openwetware.org/wiki/Biomod/2013/Sendai" class="whiteSendai">Top</a> 
           <a href="http://openwetware.org/wiki/Biomod/2013/Sendai/project" class="whiteSendai">Project</a>
           <a href="http://openwetware.org/wiki/Biomod/2013/Sendai/design" class="whiteSendai">Design</a> 
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           <a href="http://openwetware.org/wiki/Biomod/2013" class="whiteSendai" style="float:right;"><img src="http://openwetware.org/images/6/6e/Biomod-logo.jpg" 
                                              width="75" height="75" alt="Biomod2013" border="0"></a><br>
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           <a href="http://openwetware.org/wiki/Biomod/2013/Sendai/future" class="whiteSendai">Future</a> 
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            <a href="http://openwetware.org/wiki/Biomod/2013/Sendai"><h1 style="color:white;" ><b>Biomod<span>2013<br>&emsp; Team</span>Sendai</b></h1></a> 
   </header>

<!-- Movie -->

 <section role="main">
       <article>
           <h3>Movie</h3>
          <div align="center">
          <iframe width="640" height="480" src="//www.youtube.com/embed/8OB8ytltxwY" frameborder="0" allowfullscreen>
          </iframe></div>
       </article>

<!-- Abstract -->

<div id="content-left">

       <article>
           <h3>Abstract</h3>
           <p>DDSは薬剤を運ぶ有効なアプローチであるが、制御された薬の放出系が必要である。

私たちのプロジェクトは、構造や論理回路の設計が可能であるDNAを利用して、トリガーを元にした連鎖反応により制御された薬剤放出系を実現することである。トリガーDNAのリポソーム表面へのハイブリダイゼーション、物理的な負荷がかかることにより、リポソームを破壊する。リポソームは有効成分と、新たなトリガーを含んでおり、放出された構造物は、連鎖反応的に周囲のリポソームを破壊する。 反応を開始するトリガーDNAはリポソーム・アルギン酸二重膜に閉じ込められている。リポソーム表面には、ニッパム分子が修飾されており、37℃程度に上げることで、ニッパム分子が収縮しリポソームが破壊される。リポソーム内部に含まれるキレート剤の効果により、アルギン酸膜も破壊され、37℃条件下で両膜が破壊されると、トリガーのDNAオリガミが外に出ていく。 リポソーム表面はトリガーDNA構造体の一部と相補的な配列を持つ一本鎖DNAを多数含んでおり、トリガーDNAはリポソーム表面に多数ハイブリダイゼーションする。トリガーDNAのリポソーム表面への付着及びリポソームの破壊を顕微鏡で確かめ、リポソームの破壊を確認した(予定)。 このようなシステムの設計により、好きな時に温度を37度に上げればトリガーの放出及び有効成分の放出が可能になる。</p>

       </article>

</div>

<!-- Image -->

<div id="content-right">

       <article>
           <h3>Image</h3>

<img src="http://openwetware.org/images/c/c5/Projectcellgate.png" width="380" height="400" />

      <p>Lorem ipsum dolor sit amet, <a href="#">consectetur</a> adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in <a href="#">reprehenderit in voluptate</a> velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.</p>
           <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.</p>
           <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.</p>
           <blockquote>
               <p>Lorem ipsum dolor sit amet.</p>
               <p>- Jean Paul II</p>
           </blockquote>
           <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.</p>
           <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.</p>
       </article>

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