Biomod/2013/Sendai

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                 <a href="#"  class="whiteSendai">Blog</a>  
                 <a href="#"  class="whiteSendai">Blog</a>  
                 <a href="#"  class="whiteSendai">Twitter</a>
                 <a href="#"  class="whiteSendai">Twitter</a>
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             <a href="http://openwetware.org/wiki/Biomod/2013/Sendai" class="whiteSendai">Top</a>  
             <a href="http://openwetware.org/wiki/Biomod/2013/Sendai" class="whiteSendai">Top</a>  
             <a href="http://openwetware.org/wiki/Biomod/2013/Sendai/project" class="whiteSendai">Project</a>
             <a href="http://openwetware.org/wiki/Biomod/2013/Sendai/project" class="whiteSendai">Project</a>
             <a href="http://openwetware.org/wiki/Biomod/2013/Sendai/design" class="whiteSendai">Design</a>  
             <a href="http://openwetware.org/wiki/Biomod/2013/Sendai/design" class="whiteSendai">Design</a>  
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            <a href="http://openwetware.org/wiki/Biomod/2013/Sendai/calcuation" class="whiteSendai">Calculation</a>
             <a href="http://openwetware.org/wiki/Biomod/2013/Sendai/experiment" class="whiteSendai">Experiment</a>
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<a href="http://openwetware.org/wiki/Biomod/2013" class="whiteSendai" style="float:right;"><img src="http://openwetware.org/images/6/6e/Biomod-logo.jpg"  
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            <a href="http://openwetware.org/wiki/Biomod/2013" class="whiteSendai" style="float:right;"><img src="http://openwetware.org/images/6/6e/Biomod-logo.jpg"  
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                                               width="75" height="75" alt="Biomod2013" border="0"></a><br>
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             <a href="http://openwetware.org/wiki/Biomod/2013/Sendai/protocol" class="whiteSendai">Protocol</a>   
             <a href="http://openwetware.org/wiki/Biomod/2013/Sendai/protocol" class="whiteSendai">Protocol</a>   
             <a href="http://openwetware.org/wiki/Biomod/2013/Sendai/future" class="whiteSendai">Future</a>  
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             <a href="http://openwetware.org/wiki/Biomod/2013/Sendai"><h1 style="color:white;" ><b>Biomod<span>2013<br>&emsp; Team</span>Sendai</b></h1></a>  
             <a href="http://openwetware.org/wiki/Biomod/2013/Sendai"><h1 style="color:white;" ><b>Biomod<span>2013<br>&emsp; Team</span>Sendai</b></h1></a>  
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<br><div class="title">Lipo-HANABI</div>
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            <p>私達のプロジェクトはトリガー入力による連鎖的分子放出システムの構築を目指している。 既存のDDSでは薬剤放出のタイミングの制御が困難な事、一度の入力に対して一定の出力しか得られない事が課題である。</br>
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We are aiming at constructing a chain-reactive molecule-releasing system in this project. <br>
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この問題を克服する為、私達はある条件でトリガーDNAを放出するシステムと、その放出を起点に連鎖的にリポソームが割れる出力増幅システムの2つを構築する。</br>
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In living organisms, signal transduction is widely used in many situations. <br>
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1つ目のシステムでは、トリガーを内在したアルギン酸ゲル膜を作り、温度の上昇に伴い自発的なゲルの融解とトリガーの放出が行われる。2つ目のシステムは、リポソーム表面にトリガーをハイブリし物理的な負荷をかけ、リポソームを破壊する。破壊されるリポソームは新たなトリガーを含んでおり、放出されたトリガーは連鎖的に周囲のリポソームを破壊する。</br>
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Here we construct a signal transduction-like system through an approach of DNA nano-engineering. <br>
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本システムの実現により入力のタイミングが制御可能かつ一度の入力で大量の薬剤を出力できるDDSの創出等への応用が期待できる。</br>
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In our project, trigger DNAs and payload molecules are encapsulated in a liposome. The trigger DNA is specially designed to collapse the liposome when some initiation stimulus is applied. Once one of the liposomes collapsed, the trigger DNAs are released from the liposome and that break other liposomes in chain-reactive fashion. This mechanism of “chain-reactive burst” enables us to release a large amount of payload molecules all at once, driven by a faint trigger signal. <br>
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We believe this system offers a fundamental technique of signal transduction/amplification of various kinds of chemical or physical signals, applicable to Drug Delivery System, molecular computers and so on.<br>
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      <p>Lorem ipsum dolor sit amet, <a href="#">consectetur</a> adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in <a href="#">reprehenderit in voluptate</a> velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.</p>
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Revision as of 22:06, 26 October 2013

Biomod2013 Sendai ver2.0

Biomod2013
  Team
Sendai



Lipo-HANABI

Abstract

We are aiming at constructing a chain-reactive molecule-releasing system in this project.
In living organisms, signal transduction is widely used in many situations.
Here we construct a signal transduction-like system through an approach of DNA nano-engineering.
In our project, trigger DNAs and payload molecules are encapsulated in a liposome. The trigger DNA is specially designed to collapse the liposome when some initiation stimulus is applied. Once one of the liposomes collapsed, the trigger DNAs are released from the liposome and that break other liposomes in chain-reactive fashion. This mechanism of “chain-reactive burst” enables us to release a large amount of payload molecules all at once, driven by a faint trigger signal.
We believe this system offers a fundamental technique of signal transduction/amplification of various kinds of chemical or physical signals, applicable to Drug Delivery System, molecular computers and so on.

Movie

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