Biomod/2013/NanoUANL/Reactor

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What is a reactor?

Introduction

The CCMV capsid was considered as a continuous stirred-tank reactor with accumulation of the product.

For an enzymatic reaction of the type:

E + S \leftrightarrow ES \rightarrow E^0 + P

with a reaction rate of:

\frac{d[ES]}{dt}=k_1[E][S]-k_{-1}[ES]-k_2[ES]

We established the following in our system:

  • Uniform distribution throughout the reactor
  • K-1 >> K1 and K2
  • One enzyme per reactor/VLP
  • Tortuosity approaches zero during diffusion

Mass balance was presented as such:

INPUT = OUTPUT - DISAPPEARANCE BY REACTION + ACCUMULATION

where

Input = F0 Output = F0(1-XS) Disappearance = V(-rS Accumulation = \tfrac{d[P]}{dt}

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