Biomod/2013/NanoUANL/Reactor

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(New page: == What is a reactor? == === Introduction === The CCMV capsid was considered as a continuous stirred-tank reactor with accumulation of the product. For an enzymatic reaction of the ty...)
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== What is a reactor? ==
== What is a reactor? ==
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Mass balance was presented as such:
Mass balance was presented as such:
-
INPUT = OUTPUT - DISAPPEARANCE BY REACTION + ACCUMULATION
+
'''INTAKE= OUTFLOW- DISAPPEARANCE BY REACTION + ACCUMULATION
 +
'''
where
where
-
Input = F<sub>0</sub>
+
Intake= F<sub>0</sub>
-
Output = F<sub>0</sub>(1-X<sub>S</sub>)
+
 
 +
Outflow= F<sub>0</sub>(1-X<sub>S</sub>)
 +
 
Disappearance = V(-r<sub>S</sub>
Disappearance = V(-r<sub>S</sub>
 +
Accumulation = <math>\tfrac{d[P]}{dt}</math>
Accumulation = <math>\tfrac{d[P]}{dt}</math>
 +
 +
F<sub>0</sub> = F<sub>0</sub>(1-X<sub>S</sub>) - V(-r<sub>S</sub>) + <math>\tfrac{d[P]}{dt}</math>
 +
 +
The intake and outflow flux were determined by diffusion , considering a spherical container.
 +
 +
[[Image:CCMV2.jpg]]
 +
 +
For the simplification of the diffusion phenomenon we considered:
 +
 +
*Constant temperature
 +
*Constant pressure
 +
*Species B stays in a stationary state (it does not diffuse in A)
 +
*The container (VLP) has a spherical shape
 +
 +
A mass balance, taking into account a spherical envelope leads to:
 +
 +
<math>\frac{d}{dr}(r^2N_{Ar})=0</math>
 +
 +
where N<sub>Ar</sub> represents molar flux. For N<sub>Br</sub> we obtain:
 +
 +
<math>\frac{d}{dr}(r^2\frac{cD_{AB}}{1-x_A}\frac{dx_A}{dr})=0</math>
 +
 +
At a constant temperature the product (cD<sub>AB</sub>) is equally constant and x<sub>A</sub>=1-x<sub>B</sub>, the equation can be integrated into the following expression:
 +
 +
<math>F_A=4\pi r_1^2N_{Ar}|_{r=r1}=
 +
\frac{4\pi cD_{AB}}{1/r_1=1/r_2}
 +
\ln\frac{x_{B2}}{x_{B1}}
 +
 +
</math>

Revision as of 01:45, 12 October 2013

What is a reactor?

Introduction

The CCMV capsid was considered as a continuous stirred-tank reactor with accumulation of the product.

For an enzymatic reaction of the type:

E + S \leftrightarrow ES \rightarrow E^0 + P

with a reaction rate of:

\frac{d[ES]}{dt}=k_1[E][S]-k_{-1}[ES]-k_2[ES]

We established the following in our system:

  • Uniform distribution throughout the reactor
  • K-1 >> K1 and K2
  • One enzyme per reactor/VLP
  • Tortuosity approaches zero during diffusion

Mass balance was presented as such:

INTAKE= OUTFLOW- DISAPPEARANCE BY REACTION + ACCUMULATION

where

Intake= F0

Outflow= F0(1-XS)

Disappearance = V(-rS

Accumulation = \tfrac{d[P]}{dt}

F0 = F0(1-XS) - V(-rS) + \tfrac{d[P]}{dt}

The intake and outflow flux were determined by diffusion , considering a spherical container.

Image:CCMV2.jpg

For the simplification of the diffusion phenomenon we considered:

  • Constant temperature
  • Constant pressure
  • Species B stays in a stationary state (it does not diffuse in A)
  • The container (VLP) has a spherical shape

A mass balance, taking into account a spherical envelope leads to:

\frac{d}{dr}(r^2N_{Ar})=0

where NAr represents molar flux. For NBr we obtain:

\frac{d}{dr}(r^2\frac{cD_{AB}}{1-x_A}\frac{dx_A}{dr})=0

At a constant temperature the product (cDAB) is equally constant and xA=1-xB, the equation can be integrated into the following expression:

F_A=4\pi r_1^2N_{Ar}|_{r=r1}=
\frac{4\pi cD_{AB}}{1/r_1=1/r_2}
\ln\frac{x_{B2}}{x_{B1}}

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