Background of Project
There were many previous studies related to the spontaneous activities of biomolecules about Kinesin, which is a class of motor proteins, and walking DNA robots. But genuine nano-scale DNA motors which rotate at the stable speed were not yet created. In our project, we are aiming at creating the DNA screw system to achieve this goal. The rotation system is used to create the complex motion with any devices, such as drills, screws and clocks. Therefore we have thought that the nano-scale rotation system enables us to extend the future of DNA engineering. The DNA screw has many strong points. DNA screw is able to embed in any other DNA structures and to be assembled into more complex structures easily, because we can take engineering approaches to make DNA structures. And, the size of the structure can be easily scaled. In addition, DNA is a stable material than protein and can be used in various environments (ex. Temperature, pH and salt-density).
Vision for the future(Phase ∞)
DNA submarine is a structure which moves in a solution and transports materials. In addition, in combination with sensors using DNA Origami technology, this DNA submarine would be able to develop into autonomous DNA robots which have the function of chemotaxis.
DNA structure with the function of Phage
By using the rotary motion of this DNA screw, the motion of a phage that makes a hole on a cell wall of bacteria could be imitated artifically. And in the end, it would be possible to make an artificial phage that is entirely consisted of DNA and controlled artificially.
Rotations of DNA screw can be stabilized by raising the number of DNA spiders, and then DNA screw will become a time counting machine like a clock. It would contribute to DNA computing technology by using it as a clock of CPU.