Biomod/2013/Fukuoka
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Abstract
- Recent years, the technology of DNA origami is attracting keen interest in the synthesis of various nanostructures has been reported. If we integrate movable structures in a DNA origami various applications such as molecular detection device, molecular motor device, drug delivery system are expected. However, only a few examples of such a movable system have been reported so far.Other problem is that the synthesis of DNA origami in larger amount is not so easy that in is unrealistic to make the macroscopic-scale device which output or input the macroscopic signal such as a mechanical and one only with DNA origami. Therefore in this study, we tried to fabricate the device in which an inorganic porous substrate is combined with DNA origami. We synthesize the “DNA weathercock” which has a shaft, a blade, and a fluorescence molecule made of DNA origami. We then attach the weathercock onto the inorganic porous substrate (anodizing alumina) with regularly arranged perpendicular pores, so that the weathercock can freely rotate. We incorporate fluorescence quencher molecules on to a part of the substrate, so that the device emit fluorescence only when the liquid on the substrate flows along a specific direction.
Study motive
- A molecular detecting element, a molecular motor element, various application including the drug delivery system are expected if I incorporate movable structure in DNA origami, but there are still few such examples.In addition, the mass composition of DNA origami is not easy, and it is not realistic to make the device of the input that is mechanical and a macroscopic scale outputting only in DNA origami.
Therefore I tried the making of the new device using DNA origami in this study.
Introduction
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Problems
Solution
This study
Design
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