Biomod/2012/Tohoku/Team Sendai: Difference between revisions

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<!—二段組み本文 -->
<!—二段組み本文 -->
<text-align="center"><h1>We want to create a new channel made of DNA!!(躍動感のあるフォントが欲しい)</h1>
<text-align="center"><h1>We want to create a new channel made of DNA!</h1>
<p>
<p>
We want to create a channel that does not exist in nature. DNA is a designable molecule and has interaction with various biomolecules. Thus, a channel made of DNA enables to transport more various biomolecules against energy gradient.
We want to create a channel that does not exist in nature. DNA is a designable molecule and has interaction with various biomolecules. Thus, a channel made of DNA enables to transport more various biomolecules against energy gradient.
Line 340: Line 340:
1. In medical care, because it can transport new molecules that are unable to be transported into cells without DNA.</br>
1. In medical care, because it can transport new molecules that are unable to be transported into cells without DNA.</br>
2. For sampling what we want from cells.</br>
2. For sampling what we want from cells.</br>
3. For BIOROOMBA by compositing with artificial liposome.( Off course use for DDS)
3. For BIOROOMBA by compositing with artificial liposome.( Off course use for DDS)</br>
（図が欲しい）</br>
</p>
</p>


Revision as of 03:56, 25 October 2012

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<!-- ヘッダー --> <div id="Header"> <h1 style="margin-top:-50px;"><!--Team Sendai--><img src="http://openwetware.org/images/c/c2/Title-kai.png" ></h1> <p>Tohoku University</p> </div>

<!-- Menu --> <ul id="menu"> <li><a href="http://openwetware.org/wiki/Biomod/2012/Tohoku/Team_Sendai ">Top</a></li> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Idea ">Project</a></li> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Simulation">Simulation</a> </li> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Design">Design</a> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Experiment ">Experiment</a> <ul> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Method">Method</a> <ul> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result#Porter">Porter</a> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result#Cylinder">Cylinder</a> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result# Vesicle">Vesicle</a> </li> </ul> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result">Result</a> <ul> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result#Porter">Porter</a> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result#Cylinder">Cylinder</a> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result# Vesicle">Vesicle</a> </li> </ul> </li> </ul> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Achievement">Achievement</a> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Diary">Diary</a> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Team ">Team</a> </li> <li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/FAQ">FAQ</a> </li> </ul>


<!—二段組み本文 --> <text-align="center"><h1>We want to create a new channel made of DNA!</h1> <p> We want to create a channel that does not exist in nature. DNA is a designable molecule and has interaction with various biomolecules. Thus, a channel made of DNA enables to transport more various biomolecules against energy gradient. Such a new channel will be used…</br> 1. In medical care, because it can transport new molecules that are unable to be transported into cells without DNA.</br> 2. For sampling what we want from cells.</br> 3. For BIOROOMBA by compositing with artificial liposome.( Off course use for DDS)</br> </p>


<div id="pop"> <h2><!--Abstract-->Project Image</h2> <img src="http://openwetware.org/images/4/46/Format_D-Heart.jpg" alt="D-Heart" width="400px"><br> </div>

<div id="pop"> <h2>Movie</h2> <!-- <p>Coming soon</p> --> <br><br> <p style="text-align:center;"> <table style="border-style:solid;border-width:10px;width:400px;height:291px;background-color:black;border-color:#bbb;text-align:center;valign:middle;font-color:white;"> <tr> <td style="color:white;">Coming soon...</td> </tr> </table> </p> </div> <h1 style="width:900px;clear:left;margin:15px;"> Abstract</h1> <p style="width:900px;clear:left;margin:15px;"> &nbsp;All the creatures on Earth are made of cells. The exterior and the interior of the cell are compartmentalized by biomembranes. A nanodevice that is able to actively transport only the specific oligonucleotide through the biomembrane has a great potential to deliver siRNA into the cell or to extract mRNA expressed in the cell.<br> Here, we decided to create a novel device with such a function. <br> We have designed a cylindrical injector/extractor device made of DNA origami. Inside the cylinder, a cascade of single stranded DNAs is planted. Once the outer-most ssDNA binds to a target oligonucleotide,　the target is passed to the inner-ones one by one because of the higher bonding energy assigned to the inner ones.<br> We also investigate how the cylinder penetrates the biomembrane by using liposome as a model membrane.<br> <br> <strong>Selector</strong>: Single stranded DNA. Once the outer-most ssDNA binds to a target,　the target is passed to the inner-ones one by one.</br> <strong>Gate</strong>: Cylindrical structure connecting the inside and outside like gates. A cascade of the "Selector" is planted in this. We can use this as an injector or extractor.</br> <strong>Membrane</strong>: The exterior and the interior of the cell are compartmentalized by biomembranes. We use liposome as a model membrane.</br> </p>

<a href=" http://openwetware.org/wiki/Biomod/2012/Team_Sendai_Old">Test page</a>

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