Biomod/2012/Tohoku/Team Sendai

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<!-- ヘッダー -->
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<div id="Header">
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<h1 style="margin-top:-50px;"><!--Team Sendai--><img src="http://openwetware.org/images/c/c2/Title-kai.png" ></h1>
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<p>Tohoku University</p>
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</div>
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<!-- Menu -->
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<ul id="menu">
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<li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendai/FinalTop#">Top</a></li>
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<li>
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<a href="#">Project</a>
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<ul>
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<li>
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<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Idea">Idea</a>
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</li>
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<li>
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<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Simulation">Simulation</a>
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</li>
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<li>
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<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Design">Design</a>
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</li>
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</ul>
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</li>
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<li>
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<a href="#">Experiment</a>
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<ul>
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<li>
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<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result">Result</a>
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<ul>
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<li>
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<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result#Porter">Porter</a>
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<li>
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<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result#Cylinder">Cylinder</a> </li>
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<li> <a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Result# Vesicle">Vesicle</a>
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</li>
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</ul>
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<li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Method">Method</a> </li>
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</ul>
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</li>
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<li>
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<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Diary">Diary</a>
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</li>
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<li>
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<a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendai/Team ">Team</a>
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</li>
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</ul>
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<!—二段組み本文 -->
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<div id="pop">
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<h2><!--Abstract-->Project Image</h2>
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<img src="http://openwetware.org/images/4/46/Format_D-Heart.jpg" alt="D-Heart" width="400px"><br>
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</div>
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<div id="pop">
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<h2>Movie</h2>
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<!--
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<p>Coming soon</p>
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-->
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<br><br>
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<p style="text-align:center;">
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<table style="border-style:solid;border-width:10px;width:400px;height:291px;background-color:black;border-color:#bbb;text-align:center;valign:middle;font-color:white;">
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<tr>
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<td style="color:white;">Coming soon...</td>
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</tr>
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</table>
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</p>
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</div>
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<h1 style="width:900px;clear:left;margin:15px;">
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Abstract</h1>
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<p style="width:900px;clear:left;margin:15px;">
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&nbsp;All the creatures on Earth are made of cells. The exterior and the interior of the cell are compartmentalized by biomembranes.
 +
A nanodevice that is able to actively transport only the specific oligonucleotide through the biomembrane has a great potential to deliver siRNA into the cell or to extract mRNA expressed in the cell.<br>
 +
Here, we decided to create a novel device with such a function. <br>
 +
We have designed a cylindrical injector/extractor device made of DNA origami. Inside the cylinder, a cascade of single stranded DNAs is planted. Once the outer-most ssDNA binds to a target oligonucleotide, the target is passed to the inner-ones one by one because of the higher bonding energy assigned to the inner ones.<br>
 +
We also investigate how the cylinder penetrates the biomembrane by using liposome as a model membrane.<br>
 +
<br>
 +
<strong>Selector</strong>: Single stranded DNA. Once the outer-most ssDNA binds to a target, the target is passed to the inner-ones one by one.</br>
 +
<strong>Gate</strong>: Cylindrical structure connecting the inside and outside like gates. A cascade of the "Selector" is planted in this. We can use this as an injector or extractor.</br>
 +
<strong>Membrane</strong>: The exterior and the interior of the cell are compartmentalized by biomembranes. We use liposome as a model membrane.</br>
 +
</p>
 +
 
 +
 
 +
<a href=" http://openwetware.org/wiki/Biomod/2012/Team_Sendai_Old">Test page</a>
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</div>
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</body>
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</html>

Revision as of 04:05, 20 October 2012

Team Sendai Top

Project Image

D-Heart

Movie



Coming soon...

Abstract

 All the creatures on Earth are made of cells. The exterior and the interior of the cell are compartmentalized by biomembranes. A nanodevice that is able to actively transport only the specific oligonucleotide through the biomembrane has a great potential to deliver siRNA into the cell or to extract mRNA expressed in the cell.
Here, we decided to create a novel device with such a function.
We have designed a cylindrical injector/extractor device made of DNA origami. Inside the cylinder, a cascade of single stranded DNAs is planted. Once the outer-most ssDNA binds to a target oligonucleotide, the target is passed to the inner-ones one by one because of the higher bonding energy assigned to the inner ones.
We also investigate how the cylinder penetrates the biomembrane by using liposome as a model membrane.

Selector: Single stranded DNA. Once the outer-most ssDNA binds to a target, the target is passed to the inner-ones one by one.
Gate: Cylindrical structure connecting the inside and outside like gates. A cascade of the "Selector" is planted in this. We can use this as an injector or extractor.
Membrane: The exterior and the interior of the cell are compartmentalized by biomembranes. We use liposome as a model membrane.

Test page

Personal tools