Biomod/2012/TeamSendaiA/Top: Difference between revisions
No edit summary |
No edit summary |
||
Line 1: | Line 1: | ||
<html><head> | <html xmlns="http://www.w3.org/1999/xhtml"> | ||
</ | <head> | ||
<meta http-equiv="Content-Type" content="text/html;charset=utf-8" /> | |||
<title>Team Sendai Top</title> | |||
<style type="text/css"> | <style type="text/css"> | ||
a {color: #017acd} | |||
/* | /* コンテナ */ | ||
div#Container {width: 800px; | |||
margin-left: auto; | |||
margin-right: auto} | |||
} | |||
/* ヘッダー */ | |||
div#Header {background-color: #ffffff; | |||
padding: 28px 20px 28px} | |||
div#Header h1 {color: #006600; | |||
# | font-size: 2.00em; | ||
{ | text-align: center; | ||
margin: 0} | |||
} | |||
div#Header p {color: #006600; | |||
font-size: 1.25em; | |||
text-align: center; | |||
margin: 0} | |||
/* トップメニュー */ | |||
ul#Topmenu {font-size: 1.00em; | |||
margin-top: 0; | |||
margin-bottom: 30px; | |||
margin-left: 0; | |||
padding-left: 0; | |||
height: 30px; | |||
background-color: #006600} | |||
ul#Topmenu li {list-style-type: none; | |||
# | float: left; | ||
padding:0; | |||
margin:0; | |||
display:block} | |||
} | |||
ul#Topmenu li a {display: block; | |||
# | width: 112px; | ||
line-height: 30px; | |||
text-decoration: none; | |||
text-align: center; | |||
color: #ffffff; | |||
background-color: | background-color: #006600; | ||
} | border-right: solid 1px #ffffff} | ||
ul#Topmenu li a:hover {background-color: #009900} | |||
# | |||
background-color:# | |||
} | |||
/* | /* フッターメニュー */ | ||
# | ul#Menu2 {font-size: 1.00em; | ||
margin-top: 30px; | |||
margin-bottom: 2px; | |||
margin-left: 0; | |||
padding-left: 0; | |||
height: 30px; | |||
} | background-color: #006600} | ||
ul#Menu2 li {list-style-type: none; | |||
float: left; | |||
display:block} | |||
ul#Menu2 li a {display: block; | |||
# | width: 112px; | ||
line-height: 30px; | |||
text-decoration: none; | |||
text-align: center; | |||
color: #ffffff; | |||
} | background-color: #006600; | ||
border-right: solid 1px #ffffff} | |||
ul#Menu2 li a:hover {background-color: #009900} | |||
# | |||
background-color: | |||
} | |||
/* | /*目次*/ | ||
# | div#mokuji {width: 800px; | ||
width: | margin-left: auto; | ||
margin-right: auto; | |||
background-color: #f5f5dc} | |||
} | |||
div#mokuji h2 { background-color: # f5f5dc; | |||
font-size: 1.50em; | |||
color: #000000; | |||
line-height: 45px; | |||
padding-left: 12px; | |||
margin-bottom: 0} | |||
ol#mokuji {font-size: 1.00em; | |||
# | margin-left: 0; | ||
padding-left: 0} | |||
} | |||
/* | /* コンテンツ */ | ||
# | div#Content {width: 800px; | ||
width: | margin-left: auto; | ||
margin-right: auto} | |||
} | |||
div#Content h2 { background-color: # f5f5dc; | |||
font-size: 1.50em; | |||
color: #000000; | |||
line-height: 10px; | |||
padding-left: 12px; | |||
margin-top: 20px; | |||
margin-bottom: 0} | |||
div#Content h3 {background-color: #ffffff; | |||
background-image: url(maru-skyblue.png); | |||
background-repeat: no-repeat; | |||
background-position: 0px 2px; | |||
font-size: 0.875em; | |||
line-height: 22px; | |||
padding-left: 26px; | |||
margin-top: 30px; | |||
margin-bottom: 0; | |||
margin-left: 12px; | |||
margin-right: 12px} | |||
div#Content p {font-size: 1.25em; | |||
line-height: 1.6; | |||
margin-top: 10px; | |||
margin-left: 12px; | |||
margin-right: 12px} | |||
/* フッター */ | |||
div#Footer {color: #ffffff; | |||
background-color: #006600; | |||
margin-top: 0.00px; | |||
padding-top: 8px; | |||
padding-bottom: 8px} | |||
address {font-size: 0.75em; | |||
font-style: normal; | |||
text-align: center} | |||
</style> | </style> | ||
</head> | |||
<body> | <body> | ||
<!-- | <!-- コンテナ --> | ||
<div id=" | <div id="Container"> | ||
<div | <!-- ヘッダー --> | ||
<div id="Header"> | |||
<h1>Team Sendai</h1> | |||
<p>Tohoku University</p> | |||
</div> | </div> | ||
< | <!—トップメニュー --> | ||
</ | <ul id="Topmenu"> | ||
<li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Top">Top</a></li> | |||
<li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Project">Project</a></li> | |||
<li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Simulation">Simulation</a></li> | |||
<li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Results_%26_Discussion">Experiment</a></li> | |||
<li><a href=" http://openwetware.org/wiki/BIOMOD/2012/Team_Sendai/Movie">Diary</a></li> | |||
<li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Member ">Team</a></li> | |||
</ul> | |||
<!-- コンテンツ --> | |||
<div id="Content"> | |||
</ | <h2>Abstract</h2> | ||
<p> | |||
All the creatures on Earth are made of cells. The exterior and the interior of the cell are compartmentalized by biomembranes. A nanodevice that is able to actively transport only the specific oligonucleotide through the biomembrane has a great potential to deliver siRNA into the cell or to extract mRNA expressed in the cell. Here, we decided to create a novel device with such a function. We have designed a cylindrical injector/extractor device made of DNA origami. Inside the cylinder, a cascade of single stranded DNAs is planted. Once the outer-most ssDNA binds to a target oligonucleotide, the target is passed to the inner-ones one by one because of the higher bonding energy assigned to the inner ones. We also investigate how the cylinder penetrates the biomembrane by using liposome as a model membrane. | |||
</p> | |||
<img src="http://openwetware.org/images/4/46/Format_D-Heart.jpg" alt="D-Heart" width="790" height="602"/> | |||
<p> | |||
<strong>Selector</strong>: Single stranded DNA. Once the outer-most ssDNA binds to a target, the target is passed to the inner-ones one by one.</br> | |||
<strong>Gate</strong>: Cylindrical structure connecting the inside and outside like gates. A cascade of the "Selector" is planted in this. We can use this as an injector or extractor.</br> | |||
<strong>Membrane</strong>: The exterior and the interior of the cell are compartmentalized by biomembranes. We use liposome as a model membrane.</br> | |||
</p> | |||
<h2>Movie</h2> | |||
<p>Coming soon</p> | |||
</div> | </div> | ||
< | <!—フッターメニュー --> | ||
< | <ul id="Menu2"> | ||
< | <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Top">Top</a></li> | ||
<li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Project">Project</a></li> | |||
<li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Simulation">Simulation</a></li> | |||
<li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Results_%26_Discussion">Experiment</a></li> | |||
<li><a href=" http://openwetware.org/wiki/BIOMOD/2012/Team_Sendai/Movie">Diary</a></li> | |||
<li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Member ">Team</a></li> | |||
</ul> | |||
< | <!-- フッター --> | ||
<div id="Footer"> | |||
<div id=" | <address>Copyright (C) Team Sendai, All rights reserved.</address> | ||
< | |||
< | |||
</div> | </div> | ||
<a href="http://openwetware.org/wiki/Biomod/2012/Tohoku/Team_Sendai">Legacy--Team Sendai B HP</a> | |||
</ | |||
</div> | </div> | ||
</body> | </body> | ||
</html> | </html> |
Revision as of 02:17, 13 October 2012
<html xmlns="http://www.w3.org/1999/xhtml"> <head> <meta http-equiv="Content-Type" content="text/html;charset=utf-8" /> <title>Team Sendai Top</title> <style type="text/css">
a {color: #017acd}
/* コンテナ */ div#Container {width: 800px; margin-left: auto; margin-right: auto}
/* ヘッダー */ div#Header {background-color: #ffffff; padding: 28px 20px 28px}
div#Header h1 {color: #006600;
font-size: 2.00em; text-align: center; margin: 0}
div#Header p {color: #006600; font-size: 1.25em;
text-align: center;
margin: 0}
/* トップメニュー */ ul#Topmenu {font-size: 1.00em; margin-top: 0; margin-bottom: 30px; margin-left: 0; padding-left: 0; height: 30px; background-color: #006600}
ul#Topmenu li {list-style-type: none; float: left; padding:0; margin:0; display:block}
ul#Topmenu li a {display: block; width: 112px; line-height: 30px; text-decoration: none; text-align: center; color: #ffffff; background-color: #006600; border-right: solid 1px #ffffff}
ul#Topmenu li a:hover {background-color: #009900}
/* フッターメニュー */ ul#Menu2 {font-size: 1.00em; margin-top: 30px; margin-bottom: 2px; margin-left: 0; padding-left: 0; height: 30px; background-color: #006600}
ul#Menu2 li {list-style-type: none; float: left; display:block}
ul#Menu2 li a {display: block; width: 112px; line-height: 30px; text-decoration: none; text-align: center; color: #ffffff; background-color: #006600; border-right: solid 1px #ffffff}
ul#Menu2 li a:hover {background-color: #009900}
/*目次*/ div#mokuji {width: 800px; margin-left: auto; margin-right: auto; background-color: #f5f5dc}
div#mokuji h2 { background-color: # f5f5dc; font-size: 1.50em; color: #000000; line-height: 45px; padding-left: 12px; margin-bottom: 0}
ol#mokuji {font-size: 1.00em; margin-left: 0; padding-left: 0}
/* コンテンツ */
div#Content {width: 800px;
margin-left: auto;
margin-right: auto}
div#Content h2 { background-color: # f5f5dc; font-size: 1.50em; color: #000000; line-height: 10px; padding-left: 12px; margin-top: 20px; margin-bottom: 0}
div#Content h3 {background-color: #ffffff; background-image: url(maru-skyblue.png); background-repeat: no-repeat; background-position: 0px 2px; font-size: 0.875em; line-height: 22px; padding-left: 26px; margin-top: 30px; margin-bottom: 0; margin-left: 12px; margin-right: 12px}
div#Content p {font-size: 1.25em; line-height: 1.6; margin-top: 10px; margin-left: 12px; margin-right: 12px}
/* フッター */ div#Footer {color: #ffffff; background-color: #006600; margin-top: 0.00px; padding-top: 8px; padding-bottom: 8px}
address {font-size: 0.75em; font-style: normal; text-align: center}
</style> </head> <body>
<!-- コンテナ --> <div id="Container">
<!-- ヘッダー --> <div id="Header"> <h1>Team Sendai</h1> <p>Tohoku University</p> </div>
<!—トップメニュー --> <ul id="Topmenu"> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Top">Top</a></li> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Project">Project</a></li> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Simulation">Simulation</a></li> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Results_%26_Discussion">Experiment</a></li> <li><a href=" http://openwetware.org/wiki/BIOMOD/2012/Team_Sendai/Movie">Diary</a></li> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Member ">Team</a></li> </ul>
<!-- コンテンツ --> <div id="Content">
<h2>Abstract</h2>
<p> All the creatures on Earth are made of cells. The exterior and the interior of the cell are compartmentalized by biomembranes. A nanodevice that is able to actively transport only the specific oligonucleotide through the biomembrane has a great potential to deliver siRNA into the cell or to extract mRNA expressed in the cell. Here, we decided to create a novel device with such a function. We have designed a cylindrical injector/extractor device made of DNA origami. Inside the cylinder, a cascade of single stranded DNAs is planted. Once the outer-most ssDNA binds to a target oligonucleotide, the target is passed to the inner-ones one by one because of the higher bonding energy assigned to the inner ones. We also investigate how the cylinder penetrates the biomembrane by using liposome as a model membrane.
</p>
<img src="http://openwetware.org/images/4/46/Format_D-Heart.jpg" alt="D-Heart" width="790" height="602"/>
<p> <strong>Selector</strong>: Single stranded DNA. Once the outer-most ssDNA binds to a target, the target is passed to the inner-ones one by one.</br> <strong>Gate</strong>: Cylindrical structure connecting the inside and outside like gates. A cascade of the "Selector" is planted in this. We can use this as an injector or extractor.</br> <strong>Membrane</strong>: The exterior and the interior of the cell are compartmentalized by biomembranes. We use liposome as a model membrane.</br> </p>
<h2>Movie</h2> <p>Coming soon</p>
</div>
<!—フッターメニュー --> <ul id="Menu2"> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Top">Top</a></li> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Project">Project</a></li> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Simulation">Simulation</a></li> <li><a href=" http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Results_%26_Discussion">Experiment</a></li> <li><a href=" http://openwetware.org/wiki/BIOMOD/2012/Team_Sendai/Movie">Diary</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendaiA/Member ">Team</a></li> </ul>
<!-- フッター --> <div id="Footer"> <address>Copyright (C) Team Sendai, All rights reserved.</address> </div>
<a href="http://openwetware.org/wiki/Biomod/2012/Tohoku/Team_Sendai">Legacy--Team Sendai B HP</a>
</div>
</body> </html>