Biomod/2012/TeamSendai/Idea

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Team Sendai Top

Contents

Project

But on experiment, it is not smart that proceeing our project in order. Luckily, large number of people in our team(and most of us are fresh!). So we decided to separate our project into several part and do experiment parallelly. Our experiment separates three parts; Gate part, Porter part, and Membrane part.

Gate part is the group making the Cell-gate itself.

Porter part is the group making the function to transport the target in the channel.</br>

Membrane part is the group making liposome by using lipid.

To separate our project and finally mix, we aim to gain our achievement. And we also establish simmulation group that verifies each structure theoretically.

Project GATE

Goal

GATE is the gatekeeper that allows only the target to enter the cell. Electric repulsions from the negative charge of the DNA backbone inhibit NOT desired DNA from entering GATE.


Project PORTER

Goal

PORTER is in charge of the active transporting of the target into GATE. The first Porter is likely to be outside GATE because of its electric repulsion. Furthermore, the first Porter catches the target DNA and pull it inside the GATE by hybridizing with it. Inner Porters that have higher affinity than the first Porter pull the target inside GATE step by step.


Project MEMBRANE

Goal

reference from "the CELL"
reference from "the CELL"

As active transporter, "CELL-GATE" should work in a cell membrane. Thus, a implementation module for inserting it to membranes was designed. DNA sequences with a hydrophobic molecule (cholesterol) are situated outside and around GATE. We used liposome (artificial lipid vesicle) as a model cell membrane.


Application in future

Finally, this project aims to attach to a real cell and transport a substance to cell and from cell. Of course, this channel may have medical use. Also, it may be used for bringing some substances which are difficult to bring back from cell nowadays. In our project "CELL-GATE", we used liposome as a model of a cell membrane, but if we consider that the "CELL-GATE" is attached to liposome, it can be used as molecular robot. This robot may be used as a cleaning robot or medical sprinkling robot.

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