Biomod/2012/TeamSendai/Future Application

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Team Sendai Top

Beyond Project

Lid

Materials with positive or neutral charge can pass through the gate freely regardless of electric potential of the Gate. Therefore, we considered the idea that we modified several long, but shorter than Porter1, single-stranded DNA at the entrance of Gate. All sequences were made of only adenine in order not to interact with Porter. It is expected that they prevent non-target materials from entering the Gate, and work as a lid of the Gate. Molecular dynamics simulation suggested such design is feasible. Under the simulation condition, a bead from outside do not have electricity. Lennard-Jones potential is the trigger of the repulsion to inhibit entrance of molecules.


Movie1 : Cylinder with additional strands

Movie2 : Ordinary cylinder


Aptamer

There exists special DNA sequences called Aptamer which interact with bio molecule. If we utilize the Aptamer sequence to the Porters, we can transport various materials selectively.


Application

If a lid structures is adopted to the Cell Gate, the Gate can regulate the entrance and exit of smaller molecules.

And aptamers offer transportation of various targets with selectivity.

Thanks to these features, Cell Gate will be an artificial channel which can transport any target molecule with high selectivity,while not affecting the existence of the cell.

Cell Gate will be applied to many medical uses:

Deliver siRNA to the target region efficiently, or remove toxic substances, body waste, and so on from our body.

Moreover, we won’t be bothered any more with drug resistant cancer cells, or protozoa like malaria, because medicine can be directly delivered to these cells.