Biomod/2012/TeamSendai/Future Application

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Team Sendai Top

Beyond Project

Lid

Materials with positive or neutral charge can pass through the gate freely regardless of electric potential of the Gate. Therefore, we considered the idea that we modified several long, but shorter than Porter1, single-stranded DNA at the entrance of Gate. All sequences were made of only adenine in order not to interact with Porter. It is expected that they prevent non-target materials from entering the Gate. Molecular dynamics simulation suggested such design is feasible. Under the simulation condition, a bead from outside do not have electricity. Lennard-Jones potential is the trigger of the repulsion to inhibit entrance of molecules.


Movie1 : Cylinder with additional strands

Movie2 : Ordinary cylinder


Aptamer

If we use DNA aptamers as Porters, which have various affinity to the same target, many kinds of materials, such as metal ion, enzyme, membrane protein and so on, can be used as a target.

This image indicates DNAaptamer can attach to Porter.
This image indicates DNAaptamer can attach to Porter.


Application

If making artificial channels is achieved, we can deliver siRNA to the target region efficiently, or remove toxic molecules from our body. Moreover, we can overcome different illnesses like drug resistant cancer cells, bacteria or protozoa (like malaria), because we can deliver medicine directly to these cells through artificial channels.

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