Team Sendai Top
Materials of positive or neutral charge can pass through the gate freely regardless of electric potential of the Gate.
Therefore, we considered the idea that we modified several long, but shorter than Porter 1, single-stranded DNA at the entrance of Gate.
All sequences were made of only adenine in order not to interact with Porter. It is expected that they prevent non-target materials from entering the Gate. Molecular dynamics simulation showed such design was feasible.
If we use DNA aptamers as Porters, which have various affinity to the same target, many kinds of materials, such as metal ion, enzyme, membrane protein and so on, can be used as a target.
Example of the application
If making artificial channels is achieved,we can deliver siRNA to the target region efficiently, or remove toxic molecules from our body. Moreover, we can conquest drug resistant cancer cells, bacteria, or protozoa like malaria, because we can deliver medicine directly to these cells thruogh the artificial channels.