Biomod/2012/TeamSendai/Future Application

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Team Sendai Top

Expanded idea

Lid

Materials of positive or neutral charge can pass freely regardless of electric potential of the Gate. Therefore, we considered the idea that we modify several long, but shorter than Porter 1, single-stranded DNA at the entrance of Gate. Designing the sequence of them all adenine not to interact with Porter. It is expected that they prevent invasion. Molecular dynamics simulation showed such design was feasible.

Aptamer

If we use DNA aptamers as Porters, which have various affinity to the same target, many kinds of materials, such as metal ion, enzyme, membrane protein and so on, can be used as a target.

Example of the application

If making artificial channels is achieved,we can deliver siRNA to the target region  efficiently, or remove toxic molecules from our body. Moreover, we can conquest drug resistant cancer cells, bacteria, or protozoa like malaria, because we can deliver medicine directly to these cells thruogh the artificial channels.

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