Biomod/2012/TeamSendai/Future Application

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(New page: {{:Biomod/2012/Tohoku/Team_Sendai/header}} <html> <body> <div id="Container"> <h1>Expanded idea</h1> <h2>Lid</h2> <h2>Aptamer</h2> <h1>Example of the application</h1> </div> </body> <...)
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<h1>Expanded idea</h1>
<h1>Expanded idea</h1>
<h2>Lid</h2>
<h2>Lid</h2>
 +
Materials of positive charge or neutral can pass freely regardless of electric potential of the Gate.
 +
Therefore, we consider the idea that we modify several long, but shorter than Porter 1, single-stranded DNA at the entrance of Gate.
 +
Designing the sequence of them all adenine not to interact with Porter. iIt is expectedthat they prevent invasion. Molecular dynamics simulation showed such design is feasible.
<h2>Aptamer</h2>
<h2>Aptamer</h2>
 +
If we use DNA aptamers as Porters, which have various affinity to the same target, many kinds of materials, such as metal ion, enzyme, membrane protein and so on, can be used as a target
<h1>Example of the application</h1>
<h1>Example of the application</h1>
-
 
+
If making artificial channels is achieved,we can deliver siRNA to the target region  efficiently, or remove toxic molecules from our body. Moreover, we can conquest drug resistant cancer cells, bacteria, or protozoa like malaria, because we can deliver medicine directly to these cells thruogh the artificial channels.
</div>
</div>

Revision as of 01:35, 27 October 2012

Team Sendai Top

Expanded idea

Lid

Materials of positive charge or neutral can pass freely regardless of electric potential of the Gate. Therefore, we consider the idea that we modify several long, but shorter than Porter 1, single-stranded DNA at the entrance of Gate. Designing the sequence of them all adenine not to interact with Porter. iIt is expectedthat they prevent invasion. Molecular dynamics simulation showed such design is feasible.

Aptamer

If we use DNA aptamers as Porters, which have various affinity to the same target, many kinds of materials, such as metal ion, enzyme, membrane protein and so on, can be used as a target

Example of the application

If making artificial channels is achieved,we can deliver siRNA to the target region  efficiently, or remove toxic molecules from our body. Moreover, we can conquest drug resistant cancer cells, bacteria, or protozoa like malaria, because we can deliver medicine directly to these cells thruogh the artificial channels.

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