Biomod/2012/TU Dresden/Nanosaurs/Project/References: Difference between revisions
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vesicles with the complementary origami system can bind to specific vesicles in determined | vesicles with the complementary origami system can bind to specific vesicles in determined | ||
orientations, thus establishing a highly complex and organized network. </p> | orientations, thus establishing a highly complex and organized network. </p> | ||
<div class="img_right img_link"> | <div class="img_right img_link"> | ||
<a rel="lightbox" href="http://www.openwetware.org/images/9/96/BM12_nanosaurs_Network_clustering.jpg"> | <a rel="lightbox" href="http://www.openwetware.org/images/9/96/BM12_nanosaurs_Network_clustering.jpg"> | ||
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<h4> 2. Molecular fishing:</h4> | <h4> 2. Molecular fishing:</h4> | ||
<p>The inherent capability of the tethering system can be used to ‘fish’ certain target species from the blood or other solutions. The catcher strands can have antibodies specific to an antigen or any multi-component affinity system. For example, this system can be used to fish out any harmful peptide toxins using specific antibodies coupled to the catcher strands. It can also be used in ex-vivo applications. </p> | <p>The inherent capability of the tethering system can be used to ‘fish’ certain target species from the blood or other solutions. The catcher strands can have antibodies specific to an antigen or any multi-component affinity system. For example, this system can be used to fish out any harmful peptide toxins using specific antibodies coupled to the catcher strands. It can also be used in ex-vivo applications. </p> | ||
<div class="img_left img_link"> | <div class="img_left img_link"> | ||
<a rel="lightbox" href="http://www.openwetware.org/images/2/27/BM12_nanosaurs_Origami_fishing_v2.jpg"> | <a rel="lightbox" href="http://www.openwetware.org/images/2/27/BM12_nanosaurs_Origami_fishing_v2.jpg"> | ||
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Revision as of 20:30, 27 October 2012
<html> <!--import jquery libraries--> <script src="http://biomod-dresden-2012.googlecode.com/svn/trunk/js/jquery-1.8.2.min.js"></script> <script src="http://biomod-dresden-2012.googlecode.com/svn/trunk/js/jquery-ui-1.9.1.custom.min.js"></script> <script src="http://biomod-dresden-2012.googlecode.com/svn/trunk/js/jquery.smooth-scroll.min.js"></script> <script src="http://biomod-dresden-2012.googlecode.com/svn/trunk/js/lightbox.js"></script> <script type="text/javascript" src="http://biomod-dresden-2012.googlecode.com/svn/trunk/js/jquery.queryloader2.js"></script> <!-- progress preloading--> <script type="text/javascript" src="http://biomod-dresden-2012.googlecode.com/svn/trunk/js/superfish.js"></script> <!-- menu bar--> <script type="text/javascript" src="http://biomod-dresden-2012.googlecode.com/svn/trunk/js/jquery.hoverIntent.minified.js"></script> <!-- replaces hover for navigation--> <script type="text/javascript" src="http://biomod-dresden-2012.googlecode.com/svn/trunk/js/jquery.scrollTo-1.4.3.1-min.js"></script> <script type="text/javascript" src="http://biomod-dresden-2012.googlecode.com/svn/trunk/js/jquery.localscroll-1.2.7-min.js"></script> <!--import webfonts--> <link href='http://fonts.googleapis.com/css?family=Merriweather:400,700' rel='stylesheet' type='text/css'> <link href='http://biomod-dresden-2012.googlecode.com/svn/trunk/css/superfish.css' rel='stylesheet' type='text/css'> <link rel="stylesheet" href="http://biomod-dresden-2012.googlecode.com/svn/trunk/css/lightbox.css" type="text/css" media="screen" /> <link rel="stylesheet" href="http://code.jquery.com/ui/1.9.0/themes/base/jquery-ui.css" /> <script type"text/javascript"> // Main function that waits for the browser to be ready $(document).ready(function(){ //make css accesible, please change the alter_css to chnage the style var alter_css = $("#alter_css").html(); $("style").remove(); $('head').append('<link rel="stylesheet" href="/skins/monobook/shared.css?164" type="text/css" />'); $('head').append('<link rel="stylesheet" href="http://biomod-dresden-2012.googlecode.com/svn/trunk/nanos.css" type="text/css" />'); //additional divs $(".firstHeading").wrap('<div id="header"></div>'); $(".firstHeading").wrap('<div id="inner_header"></div>'); $(".firstHeading").wrap('<div id="title_con"></div>'); var nav = $("#nav").html(); $('#inner_header').append(nav); $('#inner_header').append('<div class="clear"></div>'); //clean up wiki framework $("#sidebar-main").remove(); $(".portlet").remove(); //fix breadcrumbs $('#contentSub').remove(); //fix heading var h1 = $(".firstHeading").text().split("/"); $(".firstHeading").text(h1[h1.length-1]); //start plugins for navigation $("ul.sf-menu").superfish({ delay: 800, // one second delay on mouseout animation: {opacity:'show',height:'show'}, // fade-in and slide-down animation speed: 'normal', // faster animation speed }); $('#main_saurs').localScroll(); $("tr:odd").addClass("odd");
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(function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); </script> <script type="text/javascript">var addthis_config = {"data_track_addressbar":false};</script> <script type="text/javascript" src="http://s7.addthis.com/js/300/addthis_widget.js#pubid=ra-508414b242f27ceb"></script> <script id="nav"> <div id="nav"> <ul id="nav" class="sf-menu"> <li><a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs">home</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Team">team</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project">project</a> <ul> <li><a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project">overview</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/DNA origami">dna origami</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/Vesicles">vesicles</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/Aptamer_lock">aptamer lock</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/Future_work">future work</a></li> </ul> </li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Lab_book">lab book</a> <ul> <li><a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Lab_book#recipes">recipes</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Lab_book#protocols">protocols</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Lab_book#downloads">downloads</a></li> </ul> </li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Gallery">gallery</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Sponsors">sponsors</a></li> </ul> </div> </script>
</html> <html> <h2>Outlook</h2> <p>We accomplished our goal of tethering vesicles of different sizes successfully. But, we were not able to include the signal driven aptamer system due to the short duration available. Thus, we plan to use the aptamer with the closed origami structure for further experiments to prove that our system is indeed controllable. We also plan to introduce this tethering system into living cells or endosomes and observe the various impacts that this system might have on vesicle fusion, internalization etc. </p> <h3>Potential applications</h3> <h4> 1. Vesicle networks:</h4> <p>Vesicle networks with a defined connectivity and orientation can be achieved with our system.
The catcher strands on the origami can be modified in several ways like having a certain complementary sequence, antibodies, biotin or any other possible modifications. Therefore, vesicles with the complementary origami system can bind to specific vesicles in determined orientations, thus establishing a highly complex and organized network. </p>
<div class="img_right img_link"> <a rel="lightbox" href="http://www.openwetware.org/images/9/96/BM12_nanosaurs_Network_clustering.jpg"> <img src="http://www.openwetware.org/images/2/22/BM12_nanosaurs_Network_clustering_s.jpg"> </a> </div>
<h4> 2. Molecular fishing:</h4>
<p>The inherent capability of the tethering system can be used to ‘fish’ certain target species from the blood or other solutions. The catcher strands can have antibodies specific to an antigen or any multi-component affinity system. For example, this system can be used to fish out any harmful peptide toxins using specific antibodies coupled to the catcher strands. It can also be used in ex-vivo applications. </p>
<div class="img_left img_link"> <a rel="lightbox" href="http://www.openwetware.org/images/2/27/BM12_nanosaurs_Origami_fishing_v2.jpg"> <img src="http://www.openwetware.org/images/0/02/BM12_nanosaurs_Origami_fishing_v2_s.jpg"> </a> </div>
</html>
