Biomod/2012/TU Dresden/Nanosaurs

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<h2>Welcome</h2>
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<p>Vivamus pharetra eleifend tincidunt. Vivamus accumsan dolor vel lacus facilisis ut tincidunt velit vehicula. Praesent ipsum orci, elementum vitae lobortis id, dictum eu justo. Duis et odio ante. Aliquam ornare eros pulvinar lacus feugiat commodo. Nunc varius nulla eget velit dignissim nec vestibulum felis ullamcorper. Vivamus ultricies massa ac sem tristique egestas vitae in ligula. Sed laoreet arcu quis urna lacinia ac tincidunt turpis egestas. In vel neque dolor. Donec et neque hendrerit nisi aliquam venenatis. Nullam viverra imperdiet bibendum. Nulla sed magna in est dapibus volutpat id ac dui. Ut vitae lorem metus. Suspendisse potenti. Aliquam et porta lorem.</p>
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<p>We, the Dresden Nanosaurs from Germany, invite you to a ride through our quest to design a stunning nano-biomolecular system for the <a href="http://biomod.net/">BIOMOD</a> competition 2012. We propose a novel biological tethering system based on the technologies of DNA origami and vesicular transport. The illustration below describes the principle of our system.
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<div id="comic"><a rel="lightbox" src="http://openwetware.org/images/7/7b/BM12_nanosaurs_Comic_all.jpg">
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</p>
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<h2>Signal-driven tethering system</h2>
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<div class="big_img"><a rel="lightbox" href="http://openwetware.org/images/7/7b/BM12_nanosaurs_Comic_all.jpg">
<img src="http://openwetware.org/images/b/bd/BM12_nanosaurs_Comic_all_m.jpg"></a>
<img src="http://openwetware.org/images/b/bd/BM12_nanosaurs_Comic_all_m.jpg"></a>
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<a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/DNA%20origami"><img src="http://openwetware.org/images/d/dd/BM12_nanosaursOrigami.png"></a>
<a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/DNA%20origami"><img src="http://openwetware.org/images/d/dd/BM12_nanosaursOrigami.png"></a>
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<a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/DNA%20origami"><img src="http://openwetware.org/images/4/47/BM12_nanosaursReceiver-strands.png"></a>
<a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/Aptamer_lock"><img src="http://openwetware.org/images/1/1c/BM12_nanosaursLock.png"></a>
<a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/Aptamer_lock"><img src="http://openwetware.org/images/1/1c/BM12_nanosaursLock.png"></a>
<a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/Aptamer_lock"><img src="http://openwetware.org/images/5/5b/BM12_nanosaursKey.png"></a>
<a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/Aptamer_lock"><img src="http://openwetware.org/images/5/5b/BM12_nanosaursKey.png"></a>
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<a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/DNA%20origami"><img src="http://openwetware.org/images/4/47/BM12_nanosaursReceiver-strands.png"></a>
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<a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/Vesicles"><img src="http://openwetware.org/images/e/e0/BM12_nanosaursCatcher-strands.png"></a>
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<a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/DNA%20origami"><img src="http://openwetware.org/images/e/e0/BM12_nanosaursCatcher-strands.png"></a>
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<a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/Vesicles"><img src="http://openwetware.org/images/d/d7/BM12_nanosaursGUV.png"></a>
<a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/Vesicles"><img src="http://openwetware.org/images/d/d7/BM12_nanosaursGUV.png"></a>
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On a central giant vesicle, illustrated as a large yellow sphere, switchable DNA origami boxes are attached on its surface. In the presence of certain signal proteins, the closed DNA origami boxes get unlocked and open up. DNA single strands that were shielded before are now accessible. Therefore they can specifically hybridize with complementary strands on smaller vesicles. Hence multiple smaller vesicles can be specifically attracted to the central giant vesicle.<br/>
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<p>Vivamus pharetra eleifend tincidunt. Vivamus accumsan dolor vel lacus facilisis ut tincidunt velit vehicula. Praesent ipsum orci, elementum vitae lobortis id, dictum eu justo. Duis et odio ante. Aliquam ornare eros pulvinar lacus feugiat commodo. Nunc varius nulla eget velit dignissim nec vestibulum felis ullamcorper. Vivamus ultricies massa ac sem tristique egestas vitae in ligula. Sed laoreet arcu quis urna lacinia ac tincidunt turpis egestas. In vel neque dolor. Donec et neque hendrerit nisi aliquam venenatis. Nullam viverra imperdiet bibendum. Nulla sed magna in est dapibus volutpat id ac dui. Ut vitae lorem metus. Suspendisse potenti. Aliquam et porta lorem.</p>
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To better understand the different components, you may click on the images below the panel.  
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</p>
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        <h2>Highlights</h2>
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        <p>Below you can see some of our most appealing results: an image of the tethering of vesicles taken with LSM (Laser Scanning Microscopy) and an AFM (Atomic Force Microscopy) image of the correct folding of the open DNA origami structure.
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<div class="big_img"><a rel="lightbox" href="http://openwetware.org/images/0/02/BM12_nanosaurs_Main_Page_Result_Picture_Final.jpg">
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<img src="http://openwetware.org/images/0/02/BM12_nanosaurs_Main_Page_Result_Picture_Final.jpg"></a>
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<div id="video"><iframe width="200" height="200" src="http://www.youtube.com/embed/HcMopZIc1Mg" frameborder="0" allowfullscreen></iframe></div>
<div id="twitter">
<div id="twitter">
<div id="follow"><a href="http://twitter.com/nanosaurs">follow us<img id="logo_twitter" src="http://openwetware.org/images/6/6b/BM12_nanosaurs_Twitter.png"></a></div>
<div id="follow"><a href="http://twitter.com/nanosaurs">follow us<img id="logo_twitter" src="http://openwetware.org/images/6/6b/BM12_nanosaurs_Twitter.png"></a></div>

Current revision

Welcome

We, the Dresden Nanosaurs from Germany, invite you to a ride through our quest to design a stunning nano-biomolecular system for the BIOMOD competition 2012. We propose a novel biological tethering system based on the technologies of DNA origami and vesicular transport. The illustration below describes the principle of our system.

Signal-driven tethering system

On a central giant vesicle, illustrated as a large yellow sphere, switchable DNA origami boxes are attached on its surface. In the presence of certain signal proteins, the closed DNA origami boxes get unlocked and open up. DNA single strands that were shielded before are now accessible. Therefore they can specifically hybridize with complementary strands on smaller vesicles. Hence multiple smaller vesicles can be specifically attracted to the central giant vesicle.
To better understand the different components, you may click on the images below the panel.

Highlights

Below you can see some of our most appealing results: an image of the tethering of vesicles taken with LSM (Laser Scanning Microscopy) and an AFM (Atomic Force Microscopy) image of the correct folding of the open DNA origami structure.

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