Biomod/2012/TU Dresden/Nanosaurs

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         <h2>Highlights</h2>
         <h2>Highlights</h2>
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         <p>Below you can see illustrated our greatest achievements; tethering of the vesicles and and correct folding of the DNA origami structure.
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         <p>Below you can see some of our most appealing achievements: an image of the tethering of vesicles taken with LSM (Laser Scanning Microscopy) and an AFM image of the correct folding of the open DNA origami structure.
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Revision as of 22:20, 27 October 2012

Welcome

We, the Dresden Nanosaurs from Germany, invite you to a ride through our quest to design a stunning nano-biomolecular system, with versatile applications. We propose a novel biological tethering system based on the technologies of DNA origami and vesicular transport. The illustration below describes the principle of our system.

Signal-driven tethering system

On a central giant vesicle, illustrated as a large yellow sphere, switchable DNA origami boxes are attached on its surface. In the presence of certain signal proteins, the closed DNA origami boxes get unlocked and open up. DNA single strands that were shielded before are now accessible. Therefore they can specifically hybridize with complementary strands on smaller vesicles. Hence multiple smaller vesicles can be specifically attracted to the central giant vesicle.
To better understand the different components, you may click on the images below the panel.

Highlights

Below you can see some of our most appealing achievements: an image of the tethering of vesicles taken with LSM (Laser Scanning Microscopy) and an AFM image of the correct folding of the open DNA origami structure.

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