Biomod/2012/TU Dresden/Nanosaurs

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<h2>Welcome</h2>
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<p>We, the Dresden Nanosaurs from Germany, invite you to a ride through our quest to design a stunning nano-biomolecular system, with versatile applications. We propose a novel biological tethering system based on the technologies of DNA origami and vesicular transport. The illustration below describes the functioning of our system.<br>
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To understand the different components of our system better, you may click on the images below the panel.  
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<h2>Signal-driven tethering system</h2>
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<a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/Vesicles"><img src="http://openwetware.org/images/d/d7/BM12_nanosaursGUV.png"></a>
<a href="http://openwetware.org/wiki/Biomod/2012/TU_Dresden/Nanosaurs/Project/Vesicles"><img src="http://openwetware.org/images/d/d7/BM12_nanosaursGUV.png"></a>
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<p>In the illustration we see a central giant vesicle. Openable DNA origami boxes are attached on the surface of this vesicle. In the presence of certain signal proteins, the closed DNA origami boxes get unlocked and open up. DNA single strands that were shielded before are now accessible. Therefore they can specifically hybridize with complementary strands on smaller vesicles. Hence multiple smaller vesicles are tethered to the central giant vesicle.</p>
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<p>Vivamus pharetra eleifend tincidunt. Vivamus accumsan dolor vel lacus facilisis ut tincidunt velit vehicula. Praesent ipsum orci, elementum vitae lobortis id, dictum eu justo. Duis et odio ante. Aliquam ornare eros pulvinar lacus feugiat commodo. Nunc varius nulla eget velit dignissim nec vestibulum felis ullamcorper. Vivamus ultricies massa ac sem tristique egestas vitae in ligula. Sed laoreet arcu quis urna lacinia ac tincidunt turpis egestas. In vel neque dolor. Donec et neque hendrerit nisi aliquam venenatis. Nullam viverra imperdiet bibendum. Nulla sed magna in est dapibus volutpat id ac dui. Ut vitae lorem metus. Suspendisse potenti. Aliquam et porta lorem.</p>
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        <h2>Highlights</h2>
<div class="big_img"><a rel="lightbox" src="http://openwetware.org/images/7/7b/BM12_nanosaurs_Comic_all.jpg">
<div class="big_img"><a rel="lightbox" src="http://openwetware.org/images/7/7b/BM12_nanosaurs_Comic_all.jpg">
<img src="http://openwetware.org/images/b/bd/BM12_nanosaurs_Comic_all_m.jpg"></a>
<img src="http://openwetware.org/images/b/bd/BM12_nanosaurs_Comic_all_m.jpg"></a>

Revision as of 17:08, 27 October 2012

Welcome

We, the Dresden Nanosaurs from Germany, invite you to a ride through our quest to design a stunning nano-biomolecular system, with versatile applications. We propose a novel biological tethering system based on the technologies of DNA origami and vesicular transport. The illustration below describes the functioning of our system.
To understand the different components of our system better, you may click on the images below the panel.

Signal-driven tethering system

In the illustration we see a central giant vesicle. Openable DNA origami boxes are attached on the surface of this vesicle. In the presence of certain signal proteins, the closed DNA origami boxes get unlocked and open up. DNA single strands that were shielded before are now accessible. Therefore they can specifically hybridize with complementary strands on smaller vesicles. Hence multiple smaller vesicles are tethered to the central giant vesicle.

Highlights

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