Biomod/2011/UTAustin/Hook'em Hybridizers

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<center>'''The Counting Machine as a Modular Nanoscale DNA Component.'''</center>
<center>'''The Counting Machine as a Modular Nanoscale DNA Component.'''</center>
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One major goal of nanotechnology is to control chemical
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A major goal in nanotechnology is the find useful forms of DNA computation. This broad definition includes amplifiers, logic gates, oscillators, structural manipulations, and many more forms of controlled responses. We believe an enzyme-free, DNA toehold exchange catalyzed system that preforms the computation of “counting” can be useful in various fields of biotechnology. Counting, by our definition, relies on two main principles. The first is the input that is being counted must be the same with each pulse and the second is the output of the counter must be independent of the input quantity or concentration. That is, regardless of the amount of input used, the counter must only reach completion after the specified number of counts, or pulses.
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reactions pera logical specification. Nano-biological devices have
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been"programmed" to function as AND / OR gates, timed oscillators,
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motors,and to have other forms of controlled responses to their
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environment.We have engineered a prototype of an enzyme-free DNA
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circuit based on toeholdexchange to 'count' signal pulses
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corresponding to additions of adefined chemical. Counting, by our
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definition, needs to meet twocriteria: First, the input being being
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counted is a single chemicalused for each pulse. Second, the counter
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should output an ON signalonly when some fixed number of pulses have
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been encountered,regardless of the amount of input added in any pulse,
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and the strengthof the ON signal should be independent of the amount
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of input addedeach pulse. The molecular basis of our prototype
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count-to-two unitincludes (1) a time-delayedsignal transduction series
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coupled to an AND gate and (2) a mechanism forconstant input
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degradation.  In theory such units can be connected seriallyto make a
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counter that is capable to count to any pre-specified finitenumber.
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Revision as of 20:49, 18 October 2011

Team

  • Team name: The Hook'em Hybridizers
  • Institution: The University of Texas at Austin

About

The Counting Machine as a Modular Nanoscale DNA Component.

A major goal in nanotechnology is the find useful forms of DNA computation. This broad definition includes amplifiers, logic gates, oscillators, structural manipulations, and many more forms of controlled responses. We believe an enzyme-free, DNA toehold exchange catalyzed system that preforms the computation of “counting” can be useful in various fields of biotechnology. Counting, by our definition, relies on two main principles. The first is the input that is being counted must be the same with each pulse and the second is the output of the counter must be independent of the input quantity or concentration. That is, regardless of the amount of input used, the counter must only reach completion after the specified number of counts, or pulses.

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