Biomod/2011/TeamJapan/Tokyo/Project: Difference between revisions
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<p>The aim of our project is the construction of an autonomous micrometer-sized molecular robot. We designed and constructed a micrometer-sized molecular robot, “DNA ciliate”, named after water microorganisms, ciliate. The DNA ciliate has three independent functional modes (see the left figure): free moving mode, track walking mode, and light-irradiated gathering mode.</p> | |||
<p>The DNA ciliate consists of a micrometer-sized body and cilia. The micrometer-sized body is made of a microsphere such as a polystyrene microbead, a glass microbead, etc. The cilia are made of deoxyribozymes (single-stranded DNAs with cleaving activity). In the free moving mode, the DNA ciliate move around in a broad space based on the Brownian motion. In addition, the DNA ciliate can walk along a single-stranded DNA track using the deoxyribozyme activity. The DNA ciliate can be gathered up at a UV-irradiated area. The construction of the DNA ciliate is shown in detail below.</p> | |||
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|width="270px"|[[Image:DNA ciliate body.jpg|right|250px|DNA ciliates'body]] | |width="270px"|[[Image:DNA ciliate body.jpg|right|250px|DNA ciliates'body]] | ||
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: | :The DNA ciliate consists of a micrometer-sized body and cilia. The body of the DNA ciliate is made of a polystyrene microbead with a diameter of about 1 μm. The cilia made of deoxyribozymes are attached on the surface of the body with the amide bond (a chemical covalent bond). | ||
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|width="270px" valign="top"|[[Image:Biomod2011 Team Tokyo111028FreeMovingMode.png|250px|right]] | |width="270px" valign="top"|[[Image:Biomod2011 Team Tokyo111028FreeMovingMode.png|250px|right]] | ||
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: | :The DNA ciliate is an autonomously moving molecular robot. The first moving mode is the free moving based on the Brownian motion in an aqueous media. By the free moving mode, the DNA ciliate can move around and explore in a broad range of space. This motion is similar to a random motion of microorganisms when the microorganisms search food. | ||
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===The principle of free moving=== | ===The principle of free moving=== | ||
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:The movement by Brownian motion is described by the right equation. The left side is the mean square displacement from the | :The movement by Brownian motion is described by the right equation (1). The left side of the equation is the mean square displacement of a DNA ciliate. r is the displacement from a default position during the time Δt. The diffusion constant D is described by the right equation (2), where T is a temperature, NA is the Avogadro number, η is a viscosity coefficient, and a is the radius of the DNA ciliate body. The diffusion constant is inversely proportional to the radius of the body. Thus, a DNA ciliate with a smaller body can move more broadly. | ||
|width="300px"|[[image:Tokyo-freemoving1.png|center|280px|The equation of Brownian motion.]] | |width="300px"|[[image:Tokyo-freemoving1.png|center|280px|The equation of Brownian motion.]] | ||
[[image:Tokyo-freemoving2.png|center|240px|The equation of Brownian motion.]] | [[image:Tokyo-freemoving2.png|center|240px|The equation of Brownian motion.]] |
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<div id="navigation"> <div id="menu" style="position:static"> <ul> <li><a class="aMain" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo">Home</a></li> <li><a class="aTeam" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Team/Students">Team</a></li> <li><a class="aProject" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project">Project</a> <!-- <ul> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project">Overview</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/introduction">Introduction</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Model">Model</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Devices">Devices</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Modes">Modes</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Results">Results</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Achievements">Achievements</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Future_works">Future works</a></li> </ul> --> <li><font color="#ffffff">Results</font> <ul> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Results">Experiments</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Simulations">Simulations</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Achievements/DNA_Devices">DNA Design</a></li> </ul></li> <!-- <li><a class="Simulation" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Simulations">Simulations</a></li> <li><a class="DNA design" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Achievements/DNA_Devices">DNA Designs</a></li> --> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Achievements">Achievements</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project/Future_works">Future works</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Notebook/Protocols">Protocols</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Notebook/Lab.notebook">Notes</a></li> <li><a class="aNotebook" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Sponsors/">Sponsors</a></li> <li><a class="aSitemap" href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Sitemap">Sitemap</a></li>
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Project
The body of the DNA ciliate
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Three independent modes of the DNA ciliate
1. Free moving mode
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The principle of free moving
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2. Track walking mode
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The mechanism of track walking
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Construction of DNA tracks
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3. Light-irradiated gathering mode
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UV-switching system
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