Biomod/2011/TeamJapan/Tokyo

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<!--この上の呪文たちは必ず各ページのコピペすること-->
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:<br><i>TeamJapan Tokyo developed an autonomous micrometer-sized molecular robot, “DNA ciliate”, toward the construction of a highly functional molecular robot like a living cell.</i><br><br>
:<br><i>TeamJapan Tokyo developed an autonomous micrometer-sized molecular robot, “DNA ciliate”, toward the construction of a highly functional molecular robot like a living cell.</i><br><br>
=Project overview=
=Project overview=
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&nbsp;A living cell is an ultimate highly functional molecular robot. The high functionality results from not only its various functional molecules but also its “micrometer-sized” body that has enough space to possess the molecules. However, the sizes of already-developed molecular nanomachines are too small to include many functional molecules. Toward the construction of highly functional molecular machines and molecular robots, it is required to construct molecular robots with large (i.e., micrometer-sized) bodies. Here, we propose an autonomous micrometer-sized molecular robot “DNA ciliate”.
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&nbsp;&nbsp;A living cell is an ultimate highly functional molecular robot. The high functionality results from not only its various functional molecules but also its “micrometer-sized” body that has enough space to possess the molecules. However, the sizes of already-developed molecular nanomachines are too small to include many functional molecules. Toward the construction of highly functional molecular machines and molecular robots, it is required to construct molecular robots with large (i.e., micrometer-sized) bodies. Here, we propose an autonomous micrometer-sized molecular robot “DNA ciliate”.
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<iframe width="450" height="263" src="http://www.youtube.com/embed/uejCuQWG07A" frameborder="0" allowfullscreen></iframe>
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<br><center>This is our YOU TUBE video.</center>
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<br><center>This is our YouTube video.</center>
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<a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project"><img src="http://openwetware.org/images/2/2c/Biomod2011_Team_Tokyo_111101Biomod_three_mode_02_R.jpg" border=1 width="470" height="353"></a><br>   
<a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project"><img src="http://openwetware.org/images/2/2c/Biomod2011_Team_Tokyo_111101Biomod_three_mode_02_R.jpg" border=1 width="470" height="353"></a><br>   
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<font size="3" color="#00ff66">“DNA ciliate”</font>is an autonomous micrometer-sized molecular robot that has three independent functional modes.
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<font size="3" color="#009933">“DNA ciliate”</font>is an autonomous micrometer-sized molecular robot that has three independent functional modes.
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==DNA ciliate==
==DNA ciliate==
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[[Image:DNA ciliate body.jpg|center|250px|The body of the DNA ciliate]]
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“DNA ciliate” is an autonomous micrometer-sized molecular robot, which is inspired by water microorganisms, ciliates. A natural ciliate has a micrometer-sized body with cilia and achieves various functions such as autonomous motion with the cilia,phototaxis, etc. Similarly,<B> the DNA ciliate has a micrometer-sized body with many DNAs as cilia</B>, and it can<B> switch three different modes</B> in response to its external environment:<B> the free moving mode, the track walking mode, and the light-irradiated gathering mode.</B> (See below)
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“DNA ciliate” is an autonomous micrometer-sized molecular robot, which is inspired by water microorganisms, ciliates. A natural ciliate has a micrometer-sized body with cilia and achieves various functions such as autonomous motion with the cilia, phototaxis, etc. Similarly,<B> the DNA ciliate has a micrometer-sized body with many DNAs as cilia</B>, and it can<B> switch three different modes</B> in response to its external environment:<B> the free moving mode, the track walking mode, and the light-irradiated gathering mode.</B> (See below)
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==Three independent functional modes of DNA ciliate==
==Three independent functional modes of DNA ciliate==
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<a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project#1._Free_moving_mode"><img src="http://openwetware.org/images/d/d4/Biomod2011_Team_Tokyo_111101Biomod_FreeMovingMode_3_title.gif" border=1 width="300"></a>
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<a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project#2._Track_walking_mode"><img src="http://openwetware.org/images/a/a5/Biomod2011_Team_Tokyo_111101Biomod_TrackWalkingMode_3_title.gif" border=1 width="300"></a>
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<a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Tokyo/Project#3._Light-irradiated_gathering_mode"><img src="http://openwetware.org/images/9/9e/Biomod2011_Team_Tokyo_111101Biomod_Right-irradiatedGatheringMode_3_title.gif" border=1 width="300"></a>
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The DNA ciliate can move around in a broad range of space using the free moving mode. This mode utilizes the Brownian motion of the DNA ciliate.
The DNA ciliate can move around in a broad range of space using the free moving mode. This mode utilizes the Brownian motion of the DNA ciliate.
<br>[[Biomod/2011/TeamJapan/Tokyo/Project#1. Free moving mode|See more]]
<br>[[Biomod/2011/TeamJapan/Tokyo/Project#1. Free moving mode|See more]]
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In the track walking mode, the DNA ciliate walk directionally along a single-stranded DNA track on a plate using the cleaving activity of deoxyribozymes attached on the body of the DNA ciliate. The deoxyribozymes cleave substrate DNA strands arrayed as the track, and help the DNA ciliate move to the region of uncleaved substrate DNA step-by-step.
In the track walking mode, the DNA ciliate walk directionally along a single-stranded DNA track on a plate using the cleaving activity of deoxyribozymes attached on the body of the DNA ciliate. The deoxyribozymes cleave substrate DNA strands arrayed as the track, and help the DNA ciliate move to the region of uncleaved substrate DNA step-by-step.
<br>[[Biomod/2011/TeamJapan/Tokyo/Project#2. Track walking mode|See more]]
<br>[[Biomod/2011/TeamJapan/Tokyo/Project#2. Track walking mode|See more]]
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The DNA ciliates gather at a specific area where an ultraviolet (UV) light is irradiated; this is the light-irradiated gathering mode. To achieve this mode, a UV-switching DNA system based on the cis-trans isomerization of azobenzenes is designed.
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The DNA ciliates gather at a specific area where an ultraviolet (UV) light is irradiated; this is the light-irradiated gathering mode. To achieve this mode, a UV-switching DNA system based on the cis-trans isomerization of azobenzenes was designed.
<br>[[Biomod/2011/TeamJapan/Tokyo/Project#3. Light-irradiated gathering mode|See more]]
<br>[[Biomod/2011/TeamJapan/Tokyo/Project#3. Light-irradiated gathering mode|See more]]
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Current revision











TeamJapan Tokyo developed an autonomous micrometer-sized molecular robot, “DNA ciliate”, toward the construction of a highly functional molecular robot like a living cell.

Project overview

 

  A living cell is an ultimate highly functional molecular robot. The high functionality results from not only its various functional molecules but also its “micrometer-sized” body that has enough space to possess the molecules. However, the sizes of already-developed molecular nanomachines are too small to include many functional molecules. Toward the construction of highly functional molecular machines and molecular robots, it is required to construct molecular robots with large (i.e., micrometer-sized) bodies. Here, we propose an autonomous micrometer-sized molecular robot “DNA ciliate”.


This is our YouTube video.


“DNA ciliate”is an autonomous micrometer-sized molecular robot that has three independent functional modes.

DNA ciliate

“DNA ciliate” is an autonomous micrometer-sized molecular robot, which is inspired by water microorganisms, ciliates. A natural ciliate has a micrometer-sized body with cilia and achieves various functions such as autonomous motion with the cilia, phototaxis, etc. Similarly, the DNA ciliate has a micrometer-sized body with many DNAs as cilia, and it can switch three different modes in response to its external environment: the free moving mode, the track walking mode, and the light-irradiated gathering mode. (See below)

Three independent functional modes of DNA ciliate

The DNA ciliate can move around in a broad range of space using the free moving mode. This mode utilizes the Brownian motion of the DNA ciliate.
See more

In the track walking mode, the DNA ciliate walk directionally along a single-stranded DNA track on a plate using the cleaving activity of deoxyribozymes attached on the body of the DNA ciliate. The deoxyribozymes cleave substrate DNA strands arrayed as the track, and help the DNA ciliate move to the region of uncleaved substrate DNA step-by-step.
See more

The DNA ciliates gather at a specific area where an ultraviolet (UV) light is irradiated; this is the light-irradiated gathering mode. To achieve this mode, a UV-switching DNA system based on the cis-trans isomerization of azobenzenes was designed.
See more

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