Biomod/2011/TeamJapan/Sendai

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Current revision

Welcome!!





Project
Triangular Prism

Triangular Prism

We propose a new kind of molecular robot fully made of DNA.
To win the race, the robot need to be fast, and also need to go straight toward the goal accurately.
Our design for this rolling robot is able to follow a defined track made of DNA origami in an efficient way by means of going faster than conventional spider robots.
In near future, such molecular robot would be useful for efficient drug delivery in living beings.
Do you want to learn more about this project? We present the following contents for constructing our racing robot. You also can find a video showing our project overview in the bottom of this page.
Have fun!


Design
Observation under AFM

Simulation

Triangular Prism AFM Image Simulation
Our robot is entirely constructed of DNA molecules.Based on our molecular-dynamics computer simulation result, we designed our robot with caDNAno software. Atomic-force microscopy(AFM) is suitable for watching molecular robot race. With high-speed AFM, we checked whether the DNA structures would be made or not as the designed. Moreover, the observed results were fed back to seek the optimal condition for the experiments. We did 3D molecular dynamics simulation for rational design of our racing robot on the DNA origami field. In this simulation, the robot consists of mass points and we used the Langevin equation to describe the motion of each mass point. The parameters were tuned to represent the results from wet experiments.


YouTube video

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