Welcome to the TUM Biomod project 2011! On this page we will present a DNA origami which is used as a biosensor for DNA small molecule interactions. We would like to give you an overview about this project, how we got there, which difficulties we had to face and of course you also have the chance to get to know us a little bit.
It is known that small DNA-binding molecules including intercalators and groove binders cause changes in the geometry of double-helical DNA. The challenge is that there are changes in length as well as in the twist of the helix.
Basically our strategy was to design an origami which could be investigated with a TEM and was also suitable for FRET experiments performed both as bulk and single molecule measurements.
To find out more about The U we highly recommend to watch the video. In case afterwards you are even more interested in our U take the tour and browse this page...
Biomod is an international competition around bionanotechnology. Student teams are given the opportunity to develop their own projects. Starting with nothing but a bunch of ideas which are developed to a more detailed concept, experiments have to be designed, performed and evaluated. Finally the teams present their results at a jamboree at Harvard University.