Biomod/2011/LMU/FolD'N'Assemble/Project: Difference between revisions
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DNA, as a building material, is very easy and safe to work with. So the idea to use it as a delivery vehicle came up naturally. When molecules are transported into a cell (endocytosis), they are absorbed by endosomes. The endosomes lower their pH value to 4-5. We want to use that process of pH change to open our container and release its payload. | DNA, as a building material, is very easy and safe to work with. So the idea to use it as a delivery vehicle came up naturally. When molecules are transported into a cell (endocytosis), they are absorbed by endosomes. The endosomes lower their pH value to 4-5. We want to use that process of pH change to open our container and release its payload. | ||
[[Image: | The container consists of two identical halves, that connect to form a closed cylinder. The connection is the only part sensitive to the pH change and can be adjusted to dissolve at an specific pH value, without modifying the core structures. | ||
[[Image:dimerisation.gif]] | |||
Revision as of 13:19, 22 August 2011
The Project
For our project we decided on designing a DNA based drug delivery vehicle.
DNA, as a building material, is very easy and safe to work with. So the idea to use it as a delivery vehicle came up naturally. When molecules are transported into a cell (endocytosis), they are absorbed by endosomes. The endosomes lower their pH value to 4-5. We want to use that process of pH change to open our container and release its payload.
The container consists of two identical halves, that connect to form a closed cylinder. The connection is the only part sensitive to the pH change and can be adjusted to dissolve at an specific pH value, without modifying the core structures.
