Biomod/2011/Harvard/HarvarDNAnos:Results: Difference between revisions
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{{Template:Biomod/2011/Harvard/HarvardDNAnos}} | {{Template:Biomod/2011/Harvard/HarvardDNAnos}} | ||
= | =Results Overview= | ||
'''We have accomplished the following:''' | '''We have accomplished the following:''' | ||
*'''With our original rectangular box design, we have developed a system that can trap, hold, and release nanocargo.''' | *'''With our original rectangular box design, we have developed a system that can trap, hold, and release nanocargo.''' | ||
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*'''We are now one step closer to achieving simpler signal amplification, more complex logic gates, and submarine-like drug delivery.''' | *'''We are now one step closer to achieving simpler signal amplification, more complex logic gates, and submarine-like drug delivery.''' | ||
=Box Container= | |||
[[Image:Barrelgoldlidgold2.tif|thumb|150px|Figure 1. Box with Enclosed Gold]] | [[Image:Barrelgoldlidgold2.tif|thumb|150px|Figure 1. Box with Enclosed Gold]] | ||
*We designed and folded two robust origami structures: the lid and the barrel. These two structures are the components of our box. | *We designed and folded two robust origami structures: the lid and the barrel. These two structures are the components of our box. | ||
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''[[Biomod/2011/Harvard/HarvarDNAnos:Methods#Rectangular Box Design | Rectangular Box Methods]]'' | ''[[Biomod/2011/Harvard/HarvarDNAnos:Methods#Rectangular Box Design | Rectangular Box Methods]]'' | ||
=Spherical Container= | |||
[[Image:2011-08-10_spheregelpur8bp_bottom1.jpg|thumb|150px|right| Figure 2. Open spheres]] | [[Image:2011-08-10_spheregelpur8bp_bottom1.jpg|thumb|150px|right| Figure 2. Open spheres]] | ||
*We folded and imaged closed and open sphere structures | *We folded and imaged closed and open sphere structures | ||
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''[[Biomod/2011/Harvard/HarvarDNAnos:Methods#Sphere Methods| Sphere Methods]]'' | ''[[Biomod/2011/Harvard/HarvarDNAnos:Methods#Sphere Methods| Sphere Methods]]'' | ||
=Nanoparticles= | |||
*We synthesized 5nm gold particles and conjugated DNA to their surfaces | *We synthesized 5nm gold particles and conjugated DNA to their surfaces | ||
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[[Biomod/2011/Harvard/HarvarDNAnos:Results_AuNP | ''Continue reading...'']] | [[Biomod/2011/Harvard/HarvarDNAnos:Results_AuNP | ''Continue reading...'']] | ||
=Photo-cleavage= | |||
* We demonstrated photo-cleavage of strands with internal photo-cleavable spacers | * We demonstrated photo-cleavage of strands with internal photo-cleavable spacers | ||
* We outlined a process for the use of photo-cleavable spacers as a means to open our containers and solubilize our cargo | * We outlined a process for the use of photo-cleavable spacers as a means to open our containers and solubilize our cargo | ||
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[[Biomod/2011/Harvard/HarvarDNAnos:Results_PC | ''Continue reading...'']] | [[Biomod/2011/Harvard/HarvarDNAnos:Results_PC | ''Continue reading...'']] | ||
=Tools and Parts= | |||
*[[Biomod/2011/Harvard/HarvarDNAnos:SphereCAD | SphereCAD]] | *[[Biomod/2011/Harvard/HarvarDNAnos:SphereCAD | SphereCAD]] | ||
*[[Biomod/2011/Harvard/HarvarDNAnos:caDNAnoFiles | Repository of caDNAno Files]] | *[[Biomod/2011/Harvard/HarvarDNAnos:caDNAnoFiles | Repository of caDNAno Files]] | ||
Revision as of 01:43, 2 November 2011
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Results Overview
We have accomplished the following:
- With our original rectangular box design, we have developed a system that can trap, hold, and release nanocargo.
- We have also opened Han’s sphere in preparation for future nanocargo encapsulation.
- We are now one step closer to achieving simpler signal amplification, more complex logic gates, and submarine-like drug delivery.
Box Container
- We designed and folded two robust origami structures: the lid and the barrel. These two structures are the components of our box.
- We demonstrated that we can close and open the box with high efficiency.
- We demonstrated that we can attach AuNP cargo to our lids and/or our barrels and then close the box, placing the AuNP cargo within the box.
- We demonstrated that we can photocleave the AuNP cargo off of our lids, solubilizing the cargo.
See also: Rectangular Box Design, Rectangular Box Methods
Spherical Container
- We folded and imaged closed and open sphere structures
- We began the process of testing lock mechanisms to allow transitions between the closed and open states
See also: Sphere Design, Sphere Methods
Nanoparticles
- We synthesized 5nm gold particles and conjugated DNA to their surfaces
- We conjugated DNA to commercially available 5 nm gold nanoparticles
- We integrated AuNP-DNA conjugates into our rectangular box design
Photo-cleavage
- We demonstrated photo-cleavage of strands with internal photo-cleavable spacers
- We outlined a process for the use of photo-cleavable spacers as a means to open our containers and solubilize our cargo
Tools and Parts
