Biomod/2011/Harvard/HarvarDNAnos

From OpenWetWare

< Biomod | 2011
Revision as of 14:40, 6 November 2011 by Evan Wu (Talk | contribs)
Jump to: navigation, search


Home              Mission              Process              Designs              Results              Resources              Team


News

We won 3rd Place at BIOMOD: The International Bio-molecular Design Competition. Please also check out the websites of all of our incredible competitors. Congrats to everyone!

DNA Origami Containers

Previous work has showcased the use of scaffolded DNA origami to self-assemble nanoscale, three-dimensional shapes with enclosed, hollow interiors. We explore the possibility of using such structures to load, entrap, and release soluble nanoscale cargo, with potential future applications in drug delivery and molecular signal amplification. Specifically, we design a rectangular box structure that can encapsulate gold nanoparticles and subsequently release them by a two-step process: a) photocleavage, which solubilizes the nanoparticle within the box, and b) introduction of a DNA signal, which opens the box by strand-displacement. We further investigate the use of an existing spherical origami design for similar purposes, and demonstrate opening of the sphere.

Video

Presentation

<style type="text/css" media="screen">.prezi-player { width: 550px; } .prezi-player-links { text-align: center; }</style><object id="prezi_uj6xu0za4jti" name="prezi_uj6xu0za4jti" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" width="550" height="400"><param name="movie" value="http://prezi.com/bin/preziloader.swf"/><param name="allowfullscreen" value="true"/><param name="allowscriptaccess" value="always"/><param name="bgcolor" value="#ffffff"/><param name="flashvars" value="prezi_id=uj6xu0za4jti&lock_to_path=1&color=ffffff&autoplay=no&autohide_ctrls=0"/><embed id="preziEmbed_uj6xu0za4jti" name="preziEmbed_uj6xu0za4jti" src="http://prezi.com/bin/preziloader.swf" type="application/x-shockwave-flash" allowfullscreen="true" allowscriptaccess="always" width="550" height="400" bgcolor="#ffffff" flashvars="prezi_id=uj6xu0za4jti&lock_to_path=1&color=ffffff&autoplay=no&autohide_ctrls=0"></embed></object>

Thank you

Locations of visitors to this page

Personal tools