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{{Template:Biomod/2011/Harvard/HarvardDNAnos}}
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<html><a href= http://openwetware.org/wiki/Biomod/2011/Harvard/HarvarDNAnos:Results><img src = http://openwetware.org/images/a/ac/Hdna_2011_logo1.png width=800px></a></html>
=News=
'''2012/02/16''': We are now recruiting for next year's Harvard BIOMOD team! Please contact Mingjie.Dai@wyss.harvard.edu if you are interested!
'''2011/11/05''': We won '''3rd Place''' at [http://biomod.net/ The International Bio-molecular Design Competition]! Please also check out the [[Biomod/2011 | websites of all of our incredible competitors]]. Congrats to everyone!


=DNA Origami Containers=
Previous work has showcased the use of scaffolded DNA origami to self-assemble nanoscale, three-dimensional shapes with enclosed, hollow interiors. '''We explore the possibility of using such structures to load, entrap, and release soluble nanoscale cargo''', with potential future applications in drug delivery and molecular signal amplification. Specifically, we design a rectangular box structure that can encapsulate gold nanoparticles and subsequently release them by a two-step process: a) photocleavage, which solubilizes the nanoparticle within the box, and b) introduction of a DNA signal, which opens the box by strand-displacement. We further investigate the use of an existing spherical origami design for similar purposes, and demonstrate opening of the sphere.


{|cellspacing="0"
=Presentation=
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==Project==
=Video=
<center>
<html><iframe width="560" height="315" src="http://www.youtube.com/embed/NaAE_4AFVlA" frameborder="0" allowfullscreen></iframe></html>
</center>


===Current Progress===
=Thank you=
 
<center>
*[[Biomod/2011/Harvard/HarvarDNAnos:Project | Project Outline]]
<html><a href = 'http://www.biomod.net'><img src= http://openwetware.org/images/0/0c/Biomod_logo.png width=220px> </a></html>
*[[Biomod/2011/Harvard/HarvarDNAnos:Lab_Notebook | Lab Notebook]]
<html><a href = 'http://www.wyss.harvard.edu'><img src= http://openwetware.org/images/f/f1/Wyss_logo.gif width=220px> </a></html>
*[[Biomod/2011/Harvard/HarvarDNAnos:Data&Output | Data and Output]]
<html><a href = 'http://www.hhmi.org'><img src= http://openwetware.org/images/a/ae/Hhmi2.jpg width=220px> </a></html>
*[[Biomod/2011/Harvard/HarvarDNAnos:Protocols | Protocols]]
<html><a href = 'http://www.harvard.edu'><img src= http://openwetware.org/images/9/9c/Harvard_shield_wreath.png width=100px> </a></html>
*[[Biomod/2011/Harvard/HarvarDNAnos:Tutorials | Tutorials]]
</center>
*[[Biomod/2011/Harvard/HarvarDNAnos:caDNAnoFiles | Repository of caDNAno Files]]
</div>
 
===Planning===
 
*[[Biomod/2011/Harvard/HarvarDNAnos:Schedule | Schedule]]
*[[Biomod/2011/Harvard/HarvarDNAnos:Brainstorming | Brainstorming]]
 
 
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==Team==
 
===Undergraduate Team Members===
*[[User:Evan Wu |Evan Wu]]
*[[User:Sherrie Wang  |Sherrie Wang]]
*[[User:Nick Perkons |Nick Perkons]]
*[[User:Shwinn Ricci |Shwinn Ricci]]
 
===Graduate and Post-Doctoral Mentors===
*[[User:Adam Marblestone |Adam Marblestone]]
*[[User:Tom Schaus |Tom Schaus]]
*[[User:Ralf Jungmann |Ralf Jungmann]]
*[http://yin.hms.harvard.edu/people/sun.wei/index.html Wei Sun]
*[http://wyss.harvard.edu/viewpage/26/postdocs-and-students Steve Perrault]
 
===Faculty Mentors===
*[http://research4.dfci.harvard.edu/shih/SHIH_LAB/Home.htm William Shih]
*[http://yin.hms.harvard.edu/ Peng Yin]
 
===Team Photos===
[[Image:Photo on 2011-07-01 at 16.26.jpg |250px]]
Week 4 "Team" Photo!
 
[[Image:Photo_on_2011-06-24_at_16.37.jpg | 250px]]
Week 3 Team Photo!
 
[[Image:Biomod3.jpg| 250px]]
 
Week 2 Team Photo!
 
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==Resources==
 
===[[Biomod/2011/Harvard/HarvarDNAnos:Literature | <font color="#000000">Literature</font>]]===
 
===Applications & Tools===
*[http://cadnano.org/ caDNAno]
*[http://cando.dna-origami.org/ CanDo]
*[http://usa.autodesk.com/maya/ Maya 3D Design]
*[http://success.adobe.com/en/na/sem/products/illustrator.html?kw=p&sdid=FNRPC&skwcid=TC|22174|adobe%20illustrator||S|b|7724724036 Adobe Illustrator]
*[http://www.attotron.com/cybertory/analysis/seqMassager.htm Nucleic Acid Sequence Massager]
*[http://biologylabs.utah.edu/jorgensen/wayned/ape/ ApE]
*[http://www.nupack.org NuPack]
*[http://www.wolframalpha.com WolframAlpha]
===BioMod & OWW===
*[http://www.biomod.net BioMod]
*[http://wyss.harvard.edu/ The Wyss Institute]
*[[Etiquette|OpenWetWare Etiquette]]
 
<br><br><br><br><br><br><br><br>
 
 
|}


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Latest revision as of 14:04, 16 February 2012

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Home              Mission              Process              Designs              Results              Resources              Team

<html><a href= http://openwetware.org/wiki/Biomod/2011/Harvard/HarvarDNAnos:Results><img src = http://openwetware.org/images/a/ac/Hdna_2011_logo1.png width=800px></a></html>

News

2012/02/16: We are now recruiting for next year's Harvard BIOMOD team! Please contact Mingjie.Dai@wyss.harvard.edu if you are interested! 2011/11/05: We won 3rd Place at The International Bio-molecular Design Competition! Please also check out the websites of all of our incredible competitors. Congrats to everyone!

DNA Origami Containers

Previous work has showcased the use of scaffolded DNA origami to self-assemble nanoscale, three-dimensional shapes with enclosed, hollow interiors. We explore the possibility of using such structures to load, entrap, and release soluble nanoscale cargo, with potential future applications in drug delivery and molecular signal amplification. Specifically, we design a rectangular box structure that can encapsulate gold nanoparticles and subsequently release them by a two-step process: a) photocleavage, which solubilizes the nanoparticle within the box, and b) introduction of a DNA signal, which opens the box by strand-displacement. We further investigate the use of an existing spherical origami design for similar purposes, and demonstrate opening of the sphere.

Presentation

<html><center> <div class="prezi-player"><style type="text/css" media="screen">.prezi-player { width: 550px; } .prezi-player-links { text-align: center; }</style><object id="prezi_uj6xu0za4jti" name="prezi_uj6xu0za4jti" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" width="550" height="400"><param name="movie" value="http://prezi.com/bin/preziloader.swf"/><param name="allowfullscreen" value="true"/><param name="allowscriptaccess" value="always"/><param name="bgcolor" value="#ffffff"/><param name="flashvars" value="prezi_id=uj6xu0za4jti&amp;lock_to_path=1&amp;color=ffffff&amp;autoplay=no&amp;autohide_ctrls=0"/><embed id="preziEmbed_uj6xu0za4jti" name="preziEmbed_uj6xu0za4jti" src="http://prezi.com/bin/preziloader.swf" type="application/x-shockwave-flash" allowfullscreen="true" allowscriptaccess="always" width="550" height="400" bgcolor="#ffffff" flashvars="prezi_id=uj6xu0za4jti&amp;lock_to_path=1&amp;color=ffffff&amp;autoplay=no&amp;autohide_ctrls=0"></embed></object><div class="prezi-player-links"></div></div> </center></html>

Video

<html><iframe width="560" height="315" src="http://www.youtube.com/embed/NaAE_4AFVlA" frameborder="0" allowfullscreen></iframe></html>

Thank you

<html><a href = 'http://www.biomod.net'><img src= http://openwetware.org/images/0/0c/Biomod_logo.png width=220px> </a></html> <html><a href = 'http://www.wyss.harvard.edu'><img src= http://openwetware.org/images/f/f1/Wyss_logo.gif width=220px> </a></html> <html><a href = 'http://www.hhmi.org'><img src= http://openwetware.org/images/a/ae/Hhmi2.jpg width=220px> </a></html> <html><a href = 'http://www.harvard.edu'><img src= http://openwetware.org/images/9/9c/Harvard_shield_wreath.png width=100px> </a></html>

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